CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE)

Base Information

• Chemical Name: CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE)
• CAS No.: 144750-52-7
• Molecular Formula: C16H17Cl2NO2S
• Molecular Weight: 358.288
• Hs Code.: 2934990002
• Mol file: 144750-52-7.mol

Synonyms:Clopidogrel Related Compound B;

Chemical Property of CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE)

Chemical Property:

• PSA: 57.78000
• LogP: 4.41380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

rac-ClopidogrelHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis. A tetrahydrothienopyridine as inhibitor of angiogenesis

Technology Process of CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE)

There total 9 articles about CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 2-(2-chlorophenyl)-2-(2-(thiophen-3-yl)ethylamino)acetate hydrochloride → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride (144750-52-7)

Guidance literature:

In water; at 25 - 35 ℃; for 7h;

DOI:10.1021/op300110m

Reference yield: 73.7%

methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate (144457-43-2) → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride (144750-52-7)

Guidance literature:

With hydrogenchloride; In water; acetone; at 25 ℃;

DOI:10.1080/00397911.2011.635393

Reference yield:

2-(3-thienyl)ethylamine (59311-67-0) → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride (144750-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 0.5 h / 80 - 85 °C

1.2: 20 °C

2.1: potassium carbonate / methanol; water / 0.17 h / 25 °C

2.2: 6 h / 60 - 65 °C

3.1: hydrogenchloride / water; acetone / 25 °C

With hydrogenchloride; potassium carbonate; In methanol; water; acetone;

DOI:10.1080/00397911.2011.635393

upstream raw materials:

formaldehyd

3-(2'-iodoethyl) thiophene

2-(2-chlorophenyl)glycine methyl ester hydrochloride

4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

Refernces

• 1、 Aalla, Sampath,Gilla, Goverdhan,Anumula, Raghupathi Reddy,Charagondla, Kavitha,Vummenthala, Prabhakar Reddy,Padi, Pratap Reddy. "New and efficient synthetic approaches for the regioisomeric and iminium impurities of clopidogrel bisulfate". . p. 1523 - 1526. Retrieved 2013/02/23.