2-(Piperidin-4-yl)benzoic acid

Base Information

• Chemical Name: 2-(Piperidin-4-yl)benzoic acid
• CAS No.: 782494-03-5
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 782494-03-5.mol

Synonyms:2-(4-piperidinyl)Benzoic acid;2-(PIPERIDIN-4-YL)BENZOIC ACID

Chemical Property of 2-(Piperidin-4-yl)benzoic acid

Chemical Property:

• Boiling Point: 355.5 °C at 760 mmHg
• Flash Point: 168.8 °C
• PSA: 49.33000
• Density: 1.145 g/cm³
• LogP: 2.18060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Piperidin-4-yl)benzoic acid

There total 1 articles about 2-(Piperidin-4-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(2-carboxyphenyl)piperidine-1-carboxylic acid t-butyl ester (170838-26-3) → 2-(piperidin-4-yl)benzoic acid (782494-03-5)

Guidance literature:

With trifluoroacetic acid; at 25 ℃; for 2h;

DOI:10.1016/j.bmcl.2010.08.047

Reference yield: 2.0%

2-(piperidin-4-yl)benzoic acid (782494-03-5) + 3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole (1446358-48-0) → C29H24F2N6O3

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 90 ℃; for 2h;

Reference yield:

2-(2-bromothiazol-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1196694-65-1) + 2-(piperidin-4-yl)benzoic acid (782494-03-5) → C18H16F6N2O3S (1254948-80-5)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2010.08.047

upstream raw materials:

4-(2-carboxyphenyl)piperidine-1-carboxylic acid t-butyl ester

Downstream raw materials:

C₁₈H₁₆F₆N₂O₃S

Refernces