2-Amino-5-bromo-3-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine
• CAS No.: 79456-34-1
• Molecular Formula: C6H4BrF3N2
• Molecular Weight: 241.01
• Hs Code.: 2933399090
• Mol file: 79456-34-1.mol

Synonyms:5-Bromo-3-(trifluoromethyl)-2-pyridinylamine;

Chemical Property of 2-Amino-5-bromo-3-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.139mmHg at 25°C
• Melting Point: 90 °C
• Refractive Index: 1.524
• Boiling Point: 216.6 °C at 760 mmHg
• PKA: 1.93±0.49(Predicted)
• Flash Point: 84.8 °C
• PSA: 38.91000
• Density: 1.79 g/cm³
• LogP: 3.02630
• Storage Temp.: Room temperature.

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-bromo-3-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-bromo-3-(trifluoromethyl)pyridine

There total 3 articles about 2-Amino-5-bromo-3-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-3-trifluoromethylpyridine (183610-70-0) → 5-bromo-3-(trifluoromethyl)pyridin-2-amine (79456-34-1)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2020.152430

Reference yield: 87.0%

→ 5-bromo-3-(trifluoromethyl)pyridin-2-amine (79456-34-1)

Guidance literature:

With lithium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield: 68.0%

5-bromo-2-pyridylamine (1072-97-5) + Togni's reagent II (887144-94-7) → 5-bromo-3-(trifluoromethyl)pyridin-2-amine (79456-34-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 75 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151538

upstream raw materials:

2-amino-3-trifluoromethylpyridine

5-bromo-2-pyridylamine

Togni's reagent II

Downstream raw materials:

8-(2-amino-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-3-(trifluoromethyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

8-(2-amino-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-3-(trifluoromethyl)pyridin-4-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES". Paragraph 00249. . Retrieved 2020/11/03.
• 2、 Chen, Xiaoyu,Ding, Licheng,Li, Linlin,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng. "Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent". supporting information. . Retrieved 2019/12/30.