2-Amino-3-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Amino-3-(trifluoromethyl)pyridine
• CAS No.: 183610-70-0
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.114
• Hs Code.: 29333990
• European Community (EC) Number: 663-228-5
• DSSTox Substance ID: DTXSID10375413
• Nikkaji Number: J1.071.763I
• Wikidata: Q72442853
• Mol file: 183610-70-0.mol

Synonyms:2-Amino-3-(trifluoromethyl)pyridine;183610-70-0;3-(trifluoromethyl)pyridin-2-amine;2-amino-3-trifluoromethylpyridine;3-(Trifluoromethyl)-2-pyridinamine;2-Pyridinamine, 3-(trifluoromethyl)-;3-trifluoromethyl-pyridin-2-ylamine;MFCD04972538;SCHEMBL183159;2-amino-trifluoromethyl pyridine;SCHEMBL16445619;DTXSID10375413;3-(Trifluoromethyl)pyridine-2-amine;RB1078;AKOS005064111;AB21173;AC-2718;CS-W010864;DS-0639;FS-1722;* 3-(Trifluoromethyl)-2-pyridinamine;SY002651;2-Amino-3-(trifluoromethyl)pyridine, 97%;AM20070197;FT-0649869;EN300-117174;A812801

Chemical Property of 2-Amino-3-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.28mmHg at 25°C
• Melting Point: 70-72 °C
• Refractive Index: 1.478
• Boiling Point: 203.2 °C at 760 mmHg
• PKA: 4.18±0.36(Predicted)
• Flash Point: 76.7 °C
• PSA: 38.91000
• Density: 1.368 g/cm³
• LogP: 2.26380
• Storage Temp.: Room temperature.
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 162.04048265
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

2-?Amino-?3-?(trifluoromethyl)?pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-36-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)N)C(F)(F)F
• Uses: 2-?Amino-?3-?(trifluoromethyl)?pyridine is a reagent used in the preparation of novel propanamide derivatives functioning as fatty acid amide inhibitors.

Technology Process of 2-Amino-3-(trifluoromethyl)pyridine

There total 6 articles about 2-Amino-3-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-fluoro-3-trifluoromethylpyridine (65753-52-8) → 2-amino-3-trifluoromethylpyridine (183610-70-0)

Guidance literature:

With ammonia; In water; at 130 ℃; for 10h; under 22502.3 Torr; Temperature;

Reference yield: 92.0%

(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine (911112-72-6) → 2-amino-3-trifluoromethylpyridine (183610-70-0)

Guidance literature:

(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine; With sulfuric acid; at 5 - 23 ℃; for 0.5h;

With sodium hydroxide; In water; at 0 ℃;

Reference yield: 85.0%

→ 2-amino-3-trifluoromethylpyridine (183610-70-0)

Guidance literature:

With sodium hydride; at 90 ℃; for 6h; Inert atmosphere; Sealed tube;

upstream raw materials:

methanol

8-Trifluoromethyl-tetrazolo[1,5-a]pyridine

2-chloro-3-trifluoromethyl-pyridine

(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine

Downstream raw materials:

2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine

6-bromo-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

3-(trifluoromethyl)pyridin-2-ol

Refernces

• 1、 -. "Preparation method of 2-hydroxyl-3-trifluoromethylpyridine". . . Retrieved 2018/06/21.
• 2、 -. "NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES". Page/Page column 54. . Retrieved 2010/11/27.