2-Hydroxy-3-Trifluoromethylpyridine

Base Information Edit

Chemical Name:2-Hydroxy-3-Trifluoromethylpyridine
CAS No.:22245-83-6
Molecular Formula:C6H4F3NO
Molecular Weight:163.099
Hs Code.:29333990
European Community (EC) Number:671-273-7,948-667-5
DSSTox Substance ID:DTXSID80394934
Nikkaji Number:J1.900.513E
Wikidata:Q72482059
Mol file:22245-83-6.mol

Synonyms:22245-83-6;2-Hydroxy-3-Trifluoromethylpyridine;3-(trifluoromethyl)pyridin-2-ol;2-Hydroxy-3-(trifluoromethyl)pyridine;2-Hydroxy-3-Trifluoromethyl Pyridine;3-(trifluoromethyl)-1H-pyridin-2-one;3-(Trifluoromethyl)-2-pyridone;3-(Trifluoromethyl)pyridin-2(1H)-one;2(1H)-PYRIDINONE, 3-(TRIFLUOROMETHYL)-;3-trifluoromethyl-pyridin-2-ol;MFCD00153194;3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE;Maybridge1_006338;3-trifluoromethyl-pyridone;3-trifluoromethyl-2-pyridinol;SCHEMBL908781;3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE;HTF (SSRE-021);HMS559I02;DTXSID80394934;3-(Trifluoromethyl)-2-pyridinone;DEAQPLNBCHAGLL-UHFFFAOYSA-N;BCP22483;2-hydroxy-3-trifluoromethyl-pyridine;BBL100581;CX1235;FD2043;STL554375;AKOS001434019;AKOS028108750;AB04092;CS-W002444;DS-0797;FS-1128;2-hydroxy-3-(trifluoromethyl)-pyridine;3-(TRIFLUORMETHYL)PYRIDIN-2-OL;AC-20524;SY012473;A4777;AM20061868;FT-0600957;T2600;EN300-28545;2-hydroxy-3-(trifluoromethyl)pyridine, AldrichCPR;Q-101232;Z235348047;3-(Trifluoromethyl)pyridin-2-ol, 3-(Trifluoromethyl)pyridin-2(1H)-one

Suppliers and Price of 2-Hydroxy-3-Trifluoromethylpyridine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hydroxy-3-trifluoromethylpyridine
1g
$ 70.00

TCI Chemical
3-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T)
5g
$ 135.00

TCI Chemical
3-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T)
1g
$ 43.00

SynQuest Laboratories
2-Hydroxy-3-(trifluoromethyl)pyridine 98%
5 g
$ 15.00

SynQuest Laboratories
2-Hydroxy-3-(trifluoromethyl)pyridine 98%
25 g
$ 60.00

Medical Isotopes, Inc.
2-Hydroxy-3-trifluoromethylpyridine
25 g
$ 625.00

Matrix Scientific
2-Hydroxy-3-(trifluoromethyl)pyridine 97%
25g
$ 98.00

Labseeker
2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
1kg
$ 2567.00

Labseeker
2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
500g
$ 1717.00

Labseeker
2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
100g
$ 750.00

Total 161 raw suppliers

Chemical Property of 2-Hydroxy-3-Trifluoromethylpyridine Edit

Chemical Property:

Vapor Pressure:0.0947mmHg at 25°C
Melting Point:150-153 ºC
Refractive Index:1.436
Boiling Point:223.7 ºC at 760 mmHg
PKA:9.67±0.10(Predicted)
Flash Point:89.1 ºC
PSA：33.12000
Density:1.398 g/cm³
LogP:1.80600
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:163.02449824
Heavy Atom Count:11
Complexity:239

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-3-trifluoromethylpyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,Xn
Hazard Codes:Xi,Xn,T
Statements: 36/37/38-65-20/21/22-20/21-36-25
Safety Statements: 26-36/37/39-36-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC(=O)C(=C1)C(F)(F)F
Uses 2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

Technology Process of 2-Hydroxy-3-Trifluoromethylpyridine

There total 6 articles about 2-Hydroxy-3-Trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 65753-47-1
2-chloro-3-trifluoromethyl-pyridine

: 22245-83-6
3-(trifluoromethyl)pyridine-2-(1H)-one

Guidance literature:: With acetic acid; In water; for 168h; Reflux;

Reference yield: 79.0%

: 609-71-2
1,2-dihydro-2-oxonicotinic acid

: 22245-83-6
3-(trifluoromethyl)pyridine-2-(1H)-one

Guidance literature:: With sulfur tetrafluoride; hydrogen fluoride; at 85 ℃; for 24h; Autoclave; Inert atmosphere;
DOI:10.1021/acs.joc.9b03011