3-Bromo-2-chloro-4-methoxypyridine

Base Information

• Chemical Name: 3-Bromo-2-chloro-4-methoxypyridine
• CAS No.: 144584-29-2
• Molecular Formula: C6H5BrClNO
• Molecular Weight: 222.467
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30439622
• Nikkaji Number: J502.759D
• Mol file: 144584-29-2.mol

Synonyms:3-BROMO-2-CHLORO-4-METHOXYPYRIDINE;144584-29-2;3-bromo-2-chloro-4-methoxy-pyridine;MFCD14705097;Pyridine, 3-bromo-2-chloro-4-methoxy-;SCHEMBL16198185;AMY8059;DTXSID30439622;AKOS022173393;CS-W004196;DS-7457;SY111373;FT-0686556;EN300-267102;O10953;A884790

Chemical Property of 3-Bromo-2-chloro-4-methoxypyridine

Chemical Property:

• Boiling Point: 261.243 °C at 760 mmHg
• PKA: 1.49±0.10(Predicted)
• Flash Point: 111.796 °C
• PSA: 22.12000
• Density: 1.65 g/cm³
• LogP: 2.50610
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 220.92430
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-2-Chloro-4-Methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC=C1)Cl)Br

Technology Process of 3-Bromo-2-chloro-4-methoxypyridine

There total 3 articles about 3-Bromo-2-chloro-4-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-bromo-2,4-dichloro-pyridine (144584-32-7) → 3-bromo-2-chloro-4-methoxypyridine (144584-29-2)

Guidance literature:

With sodium methylate; In methanol; for 8h; Heating;

DOI:10.1080/00397919208021549

Reference yield:

3-deazauracil (626-03-9,84719-31-3) → 3-bromo-2-chloro-4-methoxypyridine (144584-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / 48percent HBr, Br₂ / acetic acid

2: 83 percent / POCl₃, DMF / 9 h / Heating

3: 78 percent / NaOMe / methanol / 8 h / Heating

With hydrogen bromide; bromine; sodium methylate; N,N-dimethyl-formamide; trichlorophosphate; In methanol; acetic acid;

DOI:10.1080/00397919208021549

Reference yield:

3-bromo-2,4-dihydroxypyridine (96245-97-5) → 3-bromo-2-chloro-4-methoxypyridine (144584-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / POCl₃, DMF / 9 h / Heating

2: 78 percent / NaOMe / methanol / 8 h / Heating

With sodium methylate; N,N-dimethyl-formamide; trichlorophosphate; In methanol;

DOI:10.1080/00397919208021549

upstream raw materials:

3-bromo-2,4-dichloro-pyridine

3-deazauracil

3-bromo-2,4-dihydroxypyridine

Refernces