3-Bromo-2,4-dichloropyridine

Base Information

• Chemical Name: 3-Bromo-2,4-dichloropyridine
• CAS No.: 144584-32-7
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.89
• Hs Code.: 2933399090
• European Community (EC) Number: 868-940-1
• DSSTox Substance ID: DTXSID40576830
• Wikidata: Q82466700
• Mol file: 144584-32-7.mol

Synonyms:3-Bromo-2,4-dichloropyridine;144584-32-7;Pyridine, 3-bromo-2,4-dichloro-;MFCD14705096;2,4-dichloro-3-bromopyridine;SCHEMBL4478461;AMY4747;DTXSID40576830;pyridine,3-bromo-2,4-dichloro-;IEFKJYCTYZMBFL-UHFFFAOYSA-N;AKOS015998787;3-Bromo-2 pound not4-dichloropyridine;CS-W021852;GS-5587;SY114465;H10301;EN300-6495714;A884789

Chemical Property of 3-Bromo-2,4-dichloropyridine

Chemical Property:

• Melting Point: 55.5-56.5 °C
• Boiling Point: 254.206 °C at 760 mmHg
• PKA: -1.31±0.10(Predicted)
• Flash Point: 107.54 °C
• PSA: 12.89000
• Density: 1.848 g/cm³
• LogP: 3.15090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 224.87477
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-2,4-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Cl)Br)Cl

Technology Process of 3-Bromo-2,4-dichloropyridine

There total 3 articles about 3-Bromo-2,4-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-bromo-2,4-dihydroxypyridine (96245-97-5) → 3-bromo-2,4-dichloro-pyridine (144584-32-7)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; for 9h; Heating;

DOI:10.1080/00397919208021549

Reference yield:

3-deazauracil (626-03-9,84719-31-3) → 3-bromo-2,4-dichloro-pyridine (144584-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 48percent HBr, Br₂ / acetic acid

2: 83 percent / POCl₃, DMF / 9 h / Heating

With hydrogen bromide; bromine; N,N-dimethyl-formamide; trichlorophosphate; In acetic acid;

DOI:10.1080/00397919208021549

Reference yield:

3,5-dibromo-2,4-dihydroxypyridine (80791-78-2) → 3-bromo-2,4-dichloro-pyridine (144584-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; aqueous ethanolic NaOH-solution / Hydrogenation

2: phosphoryl chloride / 130 °C

With sodium hydroxide; palladium on activated charcoal; trichlorophosphate;

upstream raw materials:

3-bromo-2,4-dihydroxypyridine

3-deazauracil

3,5-dibromo-2,4-dihydroxypyridine

Downstream raw materials:

3-bromo-2-chloro-4-methoxypyridine

Refernces