80791-78-2

Basic information

• Product Name: 2,4-Dihydroxy-3,5-dibromopyridine
• Synonyms: 2,4-Dihydroxy-3,5-dibromopyridine;3,5-dibromo-2,4-dihydroxypyridine
• CAS NO: 80791-78-2
• Molecular Formula: C5H3Br2NO2
• Molecular Weight: 268.89
• Mol File: 80791-78-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Dihydroxy-3,5-dibromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dihydroxy-3,5-dibromopyridine(80791-78-2)
• EPA Substance Registry System: 2,4-Dihydroxy-3,5-dibromopyridine(80791-78-2)

Safety Data

• Hazardous Substances Data: 80791-78-2(Hazardous Substances Data)

Usage

General Description

2,4-Dihydroxy-3,5-dibromopyridine is a chemical compound with the molecular formula C5H3Br2NO2. It is a dibromopyridine derivative with two hydroxyl groups. 2,4-Dihydroxy-3,5-dibromopyridine has been studied for its potential use in pharmaceuticals, agrochemicals, and materials science. It has been shown to possess antioxidant properties, which could make it useful in the development of new drugs and treatments for various diseases. Additionally, its bromine atoms make it a potential candidate for the development of new materials with specific properties, such as flame retardancy or controlled release applications. Further research is needed to fully understand the potential applications and properties of 2,4-dihydroxy-3,5-dibromopyridine.

Upstream product

• 626-03-9 4-hydroxy-2-pyridone 
• 626-03-9 3-deazauracil 

Downstream Products

• 144584-32-7 3-bromo-2,4-dichloro-pyridine 
• 221241-37-8 2,5-dibromo-[4]pyridylamine 
• 80791-85-1 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-4-hydroxy-2-pyridinone 
• 80791-79-3 5-bromo-4-hydroxy-2-pyridinone 
• 96245-97-5 3-bromo-2,4-dihydroxypyridine 
• 80791-79-3 5-bromo-pyridine-2,4-diol 
• 856857-52-8 2,4,6-tribromopyridine 

Relevant articles and documents

Biological evaluation of pyridone alkaloids on the endocannabinoid system

Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for this biological effect remains poorly understood. In this work, we have prepared new pyridones, and tested the effect of thirteen 4-hydroxy-2-pyridone derivatives on the components of the endocannabinoid system. Investigation of binding affinities towards CB1 and CB2 receptors led to the identification of a compound binding selectively to CB1 (12). Compound 12 and a closely related derivative (11) also inhibited anandamide (AEA) hydrolysis by fatty acid amide hydrolase. Interestingly, none of the compounds tested showed any effect on 2-AG hydrolysis by monoacylglycerol lipase at 10 μM. Assessment of AEA uptake did, however, lead to the identification of four inhibitors with IC50 values in the submicromolar range and high selectivity over the other components of the endocannabinoid system.

PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS

Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR 119 G protein-coupled receptor modulator therapy. These novel compounds have the structure Formula I or Formula IA.

Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin.

[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.