(5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: (5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE
• CAS No.: 3899-07-8
• Molecular Formula: C14H22ClNO
• Molecular Weight: 219.32
• Mol file: 3899-07-8.mol

Synonyms:5-METHOXY-N-PROPYL-2-AMINOTETRALINE HYDROCHLORIDE;2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-5-METHOXY-N-PROPYL-, HYDROCHLORIDE;

Chemical Property of (5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 122-125 °C(Press: 0.5 Torr)
• PKA: 10.26±0.20(Predicted)
• PSA: 0.00000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE

There total 60 articles about (5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (3904-24-3) → (S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride (101403-24-1,3899-07-8)

Guidance literature:

With (S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine; In water; acetonitrile; at 0 - 5 ℃; for 2h;

Reference yield: 98.0%

(S)-(-)-2-(N-propylamino)-5-methoxytetraline (+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt (1222074-03-4) → (S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride (101403-24-1,3899-07-8)

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃;

Reference yield: 95.0%

(S)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide (244239-67-6) → (S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride (101403-24-1,3899-07-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 42h; Heating;

DOI:10.1016/S0968-0896(99)00073-5

upstream raw materials:

propylamine

5-methoxy-2-tetralone

ethylamine

C₁₄H₁₉NO

Downstream raw materials:

(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

rotigotine hydrochloride

(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

2-(N-propylamino)-5-methoxytetraline

Refernces

• 1、 Toussaint, Frédéric C.,Defrance, Thierry,Decouvreur, Serge,Carly, Nicolas,Merschaert, Alain. "Intensification of Free-Radical Racemization for a Non-activated Amine in a Continuous Flow Reactor". . p. 3389 - 3396. Retrieved 2020.
• 2、 Citoler, Joan,Harawa, Vanessa,Marshall, James R.,Bevinakatti, Han,Finnigan, James D.,Charnock, Simon J.,Turner, Nicholas J.. "Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination". supporting information. p. 24456 - 24460. Retrieved 2021/10/19.
• 3、 -. "Preparation method for rotigotine". . . Retrieved 2019/04/17.