2-Propylamino-5-methoxytetralin

Base Information

• Chemical Name: 2-Propylamino-5-methoxytetralin
• CAS No.: 78598-91-1
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• DSSTox Substance ID: DTXSID10437207
• Nikkaji Number: J780.841K
• ChEMBL ID: CHEMBL135152
• Mol file: 78598-91-1.mol

Synonyms:2-PROPYLAMINO-5-METHOXYTETRALIN;78598-91-1;5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine;3899-07-8;(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine;CHEMBL135152;2-Naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-N-propyl-;rac-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine;SCHEMBL604798;SCHEMBL12072682;DTXSID10437207;ICJPCRXVYMMSJY-UHFFFAOYSA-N;N-Propyl-5-methoxytetralin-2-amine;2-(N-propylamino)-5-methoxytetralin;5-methoxy-2-(N-propylamino)tetralin;BDBM50054065;AKOS022653458;2-(N-n-propylamino)-5-methoxytetralin;SB36980;PD033617;(+)-2-(N-n-propylamino)-5-methoxytetralin;(-)-2-(N-n-propylamino)-5-methoxytetralin;(-)-2-(N-n-propylamino)-5-methoxy-tetralin;(+/-)-2-(N-n-propylamino)-5-methoxytetralin;1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-naphthaleneamine

Chemical Property of 2-Propylamino-5-methoxytetralin

Chemical Property:

• PSA: 21.26000
• LogP: 2.94300
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 219.162314293
• Heavy Atom Count: 16
• Complexity: 207

Purity/Quality:

99%min ^*data from raw suppliers

5-METHOXY-N-PROPYL-2-AMINOTETRALIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCNC1CCC2=C(C1)C=CC=C2OC

Technology Process of 2-Propylamino-5-methoxytetralin

There total 11 articles about 2-Propylamino-5-methoxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (3904-24-3) → 2-(N-propylamino)-5-methoxytetraline (78598-91-1,3899-07-8)

Guidance literature:

With potassium carbonate; In 2-methyltetrahydrofuran; Product distribution / selectivity; Reflux;

Reference yield: 86.0%

propylamine (107-10-8,42939-71-9) + 5-methoxy-2-tetralone (32940-15-1) → 2-(N-propylamino)-5-methoxytetraline (78598-91-1,3899-07-8)

Guidance literature:

propylamine; 5-methoxy-2-tetralone; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.202110321

Reference yield:

C14H19NO (1374308-75-4) → 2-(N-propylamino)-5-methoxytetraline (78598-91-1,3899-07-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm900298c

upstream raw materials:

propylamine

5-methoxy-2-tetralone

ethylamine

C₁₄H₁₉NO

Downstream raw materials:

(+)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

(-)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-2-(4-nitrophenyl)-N-propylacetamide

Desthienyl-Rotigotine

Refernces

• 1、 Toussaint, Frédéric C.,Defrance, Thierry,Decouvreur, Serge,Carly, Nicolas,Merschaert, Alain. "Intensification of Free-Radical Racemization for a Non-activated Amine in a Continuous Flow Reactor". . p. 3389 - 3396. Retrieved 2020/11/03.
• 2、 -. "Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives". . . Retrieved 2013/05/08.