3-Aminocyclobutanone

Base Information

• Chemical Name: 3-Aminocyclobutanone
• CAS No.: 4640-43-1
• Molecular Formula: C4H7NO
• Molecular Weight: 85.1057
• Hs Code.: 2922399090
• Mol file: 4640-43-1.mol

Synonyms:3-Aminocyclobutanone;Cyclobutanone, 3-amino-

Chemical Property of 3-Aminocyclobutanone

Chemical Property:

• PSA: 43.09000
• LogP: 0.37690

Purity/Quality:

99%, ^*data from raw suppliers

3-AMINOCYCLOBUTANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Aminocyclobutanone

There total 4 articles about 3-Aminocyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-oxocyclobutanecarboxamide → N-3-aminocyclobutan-1-one (4640-43-1)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; In tetrahydrofuran; at 0 - 80 ℃; for 0.333333h; Solvent; Reagent/catalyst;

Reference yield:

3-oxocyclobutanecarboxylic acid (23761-23-1) → N-3-aminocyclobutan-1-one (4640-43-1)

Guidance literature:

3-oxocyclobutanecarboxylic acid; With thionyl chloride; In dichloromethane; for 3h; Reflux; Cooling with ice;

With sodium azide; In water; acetone; at 0 ℃; for 1.5h;

With hydrogenchloride; In water; toluene; at 0 - 90 ℃; for 16h;

Reference yield:

C4H5N3O → N-3-aminocyclobutan-1-one (4640-43-1)

Guidance literature:

With hydrogenchloride; water; In toluene; at 0 - 90 ℃; for 16h;

upstream raw materials:

3-oxocyclobutanecarboxylic acid

3-oxocyclobutane-1-carbonyl chloride

Downstream raw materials:

3-(tert-butyloxycarbonylamino)cyclobutan-1-one

tert-butyl (7-(3-fluorophenyl)-4-((3-oxocyclobutyl)carbamoyl)isoquinolin-1-yl)carbamate

N-(3-oxocyclobutyl)-2-naphthamide

Refernces

• 1、 -. "METHODS OF TREATING PULMONARY DISEASES AND DISORDERS". Paragraph 0099. . Retrieved 2017/07/14.
• 2、 -. "DERIVATIVES OF 3-HETEROARYLISOXAZOL-5-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS". Paragraph 0117. . Retrieved 2016/07/27.