(2,5-dibroMo-4- fluoroaniline

Base Information

• Chemical Name: (2,5-dibroMo-4- fluoroaniline
• CAS No.: 172377-05-8
• Molecular Formula: C6H4Br2FN
• Molecular Weight: 268.911
• Hs Code.: 2921420090
• Mol file: 172377-05-8.mol

Synonyms:(2,5-dibroMo-4- fluoroaniline

Chemical Property of (2,5-dibroMo-4- fluoroaniline

Chemical Property:

• PSA: 26.02000
• LogP: 3.51410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%min ^*data from raw suppliers

2,5-Dibromo-4-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,5-dibroMo-4- fluoroaniline

There total 2 articles about (2,5-dibroMo-4- fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dibromo-2-fluoro-5-nitrobenzene (366496-33-5) → 2,5-dibromo-4-fluoroaniline (172377-05-8)

Guidance literature:

With hydrogenchloride; tin(II) chloride hydrate; In ethanol; at 0 ℃; Reflux;

DOI:10.1039/c1cc14586j

Reference yield:

2,5-dibromofluorobenzene (1435-52-5) → 2,5-dibromo-4-fluoroaniline (172377-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium nitrate; trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane

2: tin(II) chloride dihdyrate; hydrogenchloride; potassium hydroxide / ethanol; water

With ammonium nitrate; hydrogenchloride; tin(II) chloride dihdyrate; trifluoroacetic acid; trifluoroacetic anhydride; potassium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1002/pola.28957

Reference yield: 84.0%

2,5-dibromo-4-fluoroaniline (172377-05-8) + acetic anhydride (108-24-7) → C8H6Br2FNO

Guidance literature:

In toluene; at 100 ℃; for 48h;

upstream raw materials:

1,4-dibromo-2-fluoro-5-nitrobenzene

2,5-dibromofluorobenzene

Downstream raw materials:

4,7-dibromo-5-fluoro-benzo[c][1,2,5]thiadiazole

N-(2,5-dibromo-4-fluorophenyl)-2,2,2-trifluoroacetamide

Refernces

• 1、 Zhang, Yong,Chien, Shang-Chieh,Chen, Kung-Shih,Yip, Hin-Lap,Sun, Ying,Davies, Joshua A.,Chen, Fang-Chung,Jen, Alex K.-Y.. "Increased open circuit voltage in fluorinated benzothiadiazole-based alternating conjugated polymers". supporting information; experimental part. p. 11026 - 11028. Retrieved 2011/11/05.