2,5-DICHLORO-3-IODOPYRIDINE

Base Information

• Chemical Name: 2,5-DICHLORO-3-IODOPYRIDINE
• CAS No.: 942206-23-7
• Molecular Formula: C₅H₂Cl₂IN
• Molecular Weight: 273.888
• Hs Code.: 2933399090
• Mol file: 942206-23-7.mol

Synonyms:2,5-DICHLORO-3-IODOPYRIDINE

Chemical Property of 2,5-DICHLORO-3-IODOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.00709mmHg at 25°C
• Melting Point: 51-53oC
• Boiling Point: 278.7oC at 760 mmHg
• PKA: -3.09±0.10(Predicted)
• Flash Point: 122.4oC
• PSA: 12.89000
• Density: 2.129g/cm3
• LogP: 2.99300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dichloro-3-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DICHLORO-3-IODOPYRIDINE

There total 1 articles about 2,5-DICHLORO-3-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5 dichloropyridine (16110-09-1) → 2,5-dichloro-3-iodopyridine (942206-23-7) + 3,6-chloro-2-iodopyridine (1353056-41-3) + 3,6-dichloro-2,4-diiodopyridine (1353056-42-4) + 2,5-dichloro-4-iodo-pyridine (796851-03-1)

Guidance literature:

2,5 dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl₂-N,N,N’,N’-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101993

Reference yield: 12.0%

2,5-dichloro-3-iodopyridine (942206-23-7) + 4-[(1R)-1-aminoethyl]cyclohexanol hydrobromide → 4-[(1R)-1-[(5-chloro-3-iodo-2-pyridyl)amino]ethyl]cyclohexanol

Guidance literature:

4-[(1R)-1-aminoethyl]cyclohexanol hydrobromide; With potassium carbonate; In methanol; at 15 ℃; for 0.5h;

2,5-dichloro-3-iodopyridine; at 130 ℃; for 16h;

DOI:10.1021/acsmedchemlett.0c00045

upstream raw materials:

2,5 dichloropyridine

Refernces