2,5-Dichloro-4-iodopyridine

Base Information

• Chemical Name: 2,5-Dichloro-4-iodopyridine
• CAS No.: 796851-03-1
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.888
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50694736
• Nikkaji Number: J2.093.808K
• Wikidata: Q72466561
• Mol file: 796851-03-1.mol

Synonyms:2,5-DICHLORO-4-IODOPYRIDINE;796851-03-1;2,5-dichloro-4-iodo-Pyridine;PYRIDINE, 2,5-DICHLORO-4-IODO-;MFCD13185538;SCHEMBL689954;2,5-dichloro-4-iodo pyridine;DTXSID50694736;IWCZLVRNVBSAPH-UHFFFAOYSA-N;AKOS015851101;AB66762;CS-W021519;AC-33342;AM806875;AS-19888;SY019689;A9926;FT-0654259;Q-101444;2,5-dichloro-4-iodo- Pyridine;2,5-Dichloro-4-iodopyridine

Chemical Property of 2,5-Dichloro-4-iodopyridine

Chemical Property:

• Melting Point: 140oC
• Refractive Index: 1.652
• Boiling Point: 278.7 °C at 760 mmHg
• Flash Point: 122.4 °C
• PSA: 12.89000
• Density: 2.129g/cm³
• LogP: 2.47870
• Storage Temp.: Refrigerated.
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 272.86090
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

98% ^*data from raw suppliers

2,5-Dichloro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CN=C1Cl)Cl)I

Technology Process of 2,5-Dichloro-4-iodopyridine

There total 3 articles about 2,5-Dichloro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,5 dichloropyridine (16110-09-1) → 2,5-dichloro-4-iodo-pyridine (796851-03-1)

Guidance literature:

2,5 dichloropyridine; With Bu(TMP)2MgLi; In tetrahydrofuran; at -10 ℃; for 2h;

With iodine; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2004.08.151

Reference yield:

2,5 dichloropyridine (16110-09-1) → 2,5-dichloro-3-iodopyridine (942206-23-7) + 3,6-chloro-2-iodopyridine (1353056-41-3) + 3,6-dichloro-2,4-diiodopyridine (1353056-42-4) + 2,5-dichloro-4-iodo-pyridine (796851-03-1)

Guidance literature:

2,5 dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl₂-N,N,N’,N’-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101993

Reference yield:

→ 2,5-dichloro-4-iodo-pyridine (796851-03-1)

Guidance literature:

upstream raw materials:

2,5 dichloropyridine

Downstream raw materials:

2,5-dichloro-4-(trifluoromethyl)pyridine

2-bromo-5-fluoro-4-(trifluoromethyl)pyridine

2-((5-chloro-2-((1-(2-oxo-2-(pyrrolidin-1-yl)-ethyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methyl-benzamide

2-((5-chloro-2-((1-(4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methyl-benzamide

Refernces

• 1、 Lu, Wenfeng,Liu, Yongqiang,Ma, Haikuo,Zheng, Jiyue,Tian, Sheng,Sun, Zhijian,Luo, Lusong,Li, Jiajun,Zhang, Hongjian,Yang, Zeng-Jie,Zhang, Xiaohu. "Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity". . p. 1980 - 1994. Retrieved 2017/09/25.
• 2、 -. "PYRIDINE COMPOUNDS". Page/Page column 117. . Retrieved 2010/01/12.