2-CHLORO-N-METHYLANILINE

Base Information

• Chemical Name: 2-CHLORO-N-METHYLANILINE
• CAS No.: 932-32-1
• Molecular Formula: C7H8 Cl N
• Molecular Weight: 141.6
• Hs Code.: 29214200
• Mol file: 932-32-1.mol

Synonyms:Aniline,o-chloro-N-methyl- (8CI); 2-Chloro-N-methylaniline;2-Chloro-N-methylbenzenamine; N-(2-Chlorophenyl)methylamine; N-Methyl-2-chloroaniline;N-Methyl-o-chloroaniline; o-Chloro-N-methylaniline

Chemical Property of 2-CHLORO-N-METHYLANILINE

Chemical Property:

• Vapor Pressure: 0.124mmHg at 25°C
• Refractive Index: n20/D 1.579(lit.)
• Boiling Point: 206.9°Cat760mmHg
• PKA: 3.17±0.10(Predicted)
• Flash Point: 78.9°C
• PSA: 12.03000
• Density: 1.088g/cm³
• LogP: 2.45470
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Not miscible or difficult to mix.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-N-methylaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Chloro-N-methylaniline is used to produce 1-methyl-2-thioacetylpyrrole in the presence of reagent Lawesson's reagent and solvent tetrahydrofuran.

Technology Process of 2-CHLORO-N-METHYLANILINE

There total 29 articles about 2-CHLORO-N-METHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-iodochlorobenzene (615-41-8) + methylamine (74-89-5) → N-methyl-2-chloroaniline (932-32-1)

Guidance literature:

With copper(l) iodide; 6,7-dihydro-5H-quinolin-8-one oxime; potassium hydroxide; In water; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201400785

Reference yield: 90.0%

2-bromo-1-chlorobenzene (694-80-4) + methylamine (74-89-5) → N-methyl-2-chloroaniline (932-32-1)

Guidance literature:

With copper(l) iodide; 6,7-dihydro-5H-quinolin-8-one oxime; potassium hydroxide; In water; at 85 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201400785

Reference yield: 84.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + o-chloroaniline (95-51-2) → N-methyl-2-chloroaniline (932-32-1)

Guidance literature:

With methanol; sodium tetrahydroborate; sodium; at 60 ℃; for 2h;

DOI:10.1039/c8ob00875b

upstream raw materials:

3-phenyl-propionic acid-(2-chloro-N-methyl-anilide)

o-chloroaniline

dimethyl sulfate

methyl iodide

Downstream raw materials:

acetic acid-(2-chloro-N-methyl-anilide)

formic acid-(2-chloro-N-methyl-anilide)

N-(2-chlorophenyl)-N-methylbenzamide

2-chloro-N-methyl-4-nitro-N-nitroso-aniline

Refernces

• 1、 Zhao, Chenxi,Tang, Chu,Li, Changhao,Ning, Wentao,Hu, Zhiye,Xin, Lilan,Zhou, Hai-Bing,Huang, Jian. "Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy". . . Retrieved 2021/05/10.
• 2、 Liu, Xiang,Loh, Teck-Peng,Qiang, Wenwen,Wang, Jing,Ye, Sen,Zhu, Longfei. "Additive-freeN-methylation of amines with methanol over supported iridium catalyst". . p. 3364 - 3375. Retrieved 2021/06/06.