tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate
• CAS No.: 1144080-27-2
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.34100
• Mol file: 1144080-27-2.mol

Synonyms:Benzamide,N-(1,4-dihydro-4-oxo-2-quinazolinyl);N'-(1,4-Dioxa-spiro[4.5]dec-8-yl)-hydrazinecarboxylic acid tert-butyl ester;N-(1,4-Dihydro-4-oxo-2-quinazolinyl)benzamide;

Chemical Property of tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate

Chemical Property:

• PSA: 72.31000
• LogP: 2.29670

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl2-(1,4-Dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate

There total 1 articles about tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.1%

cyclohexanedione monoethylene ketal (4746-97-8) + t-butoxycarbonylhydrazine (870-46-2) → tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazine-1-carboxylate (1144080-27-2)

Guidance literature:

cyclohexanedione monoethylene ketal; t-butoxycarbonylhydrazine; In methanol; at 20 ℃; for 20h;

With sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 3h; Solvent; Time;

Reference yield: 63.49%

tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazine-1-carboxylate (1144080-27-2) → 1,4-dioxaspiro[4.5]decan-8-ylhydrazine (1144080-29-4)

Guidance literature:

In water; at 100 ℃; for 12h; Time;

Reference yield: 55.0%

2,4-dichloro-N-(2,6-dimethylphenyl)pyrimidin-5-carboxamide (835633-82-4) + tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazine-1-carboxylate (1144080-27-2) → tert-butyl 2-(2-chloro-5-((2,6-dimethylphenyl)carbamoyl)pyrimidin-4-yl)-2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazin-1-carboxylate

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

upstream raw materials:

cyclohexanedione monoethylene ketal

t-butoxycarbonylhydrazine

Downstream raw materials:

1,4-dioxaspiro[4.5]decan-8-ylhydrazine

Refernces

• 1、 -. "HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 0374; 0375. . Retrieved 2016/04/20.