1,4-dioxaspiro[4.5]decan-8-ylhydrazine

Base Information

• Chemical Name: 1,4-dioxaspiro[4.5]decan-8-ylhydrazine
• CAS No.: 1144080-29-4
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.227
• Mol file: 1144080-29-4.mol

Synonyms:1,4-dioxaspiro[4.5]decan-8-ylhydrazine

Chemical Property of 1,4-dioxaspiro[4.5]decan-8-ylhydrazine

Chemical Property:

• PSA: 56.51000
• LogP: 1.22660

Purity/Quality:

98%min ^*data from raw suppliers

1,4-dioxaspiro[4.5]decan-8-ylhydrazine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-dioxaspiro[4.5]decan-8-ylhydrazine

There total 2 articles about 1,4-dioxaspiro[4.5]decan-8-ylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.49%

tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazine-1-carboxylate (1144080-27-2) → 1,4-dioxaspiro[4.5]decan-8-ylhydrazine (1144080-29-4)

Guidance literature:

In water; at 100 ℃; for 12h; Time;

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 1,4-dioxaspiro[4.5]decan-8-ylhydrazine (1144080-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 20 h / 20 °C

1.2: 3 h / 20 °C

2.1: water / 12 h / 100 °C

In methanol; water;

Reference yield: 71.0%

2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile (330792-69-3) + 1,4-dioxaspiro[4.5]decan-8-ylhydrazine (1144080-29-4) → 5-amino-3-(4-phenoxyphenyl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazole-4-carbonitrile

Guidance literature:

In ethanol; at 65 ℃; for 16h;

upstream raw materials:

tert-butyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)hydrazine-1-carboxylate

cyclohexanedione monoethylene ketal

Downstream raw materials:

6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine

Refernces

• 1、 Curran, Kevin J.,Verheijen, Jeroen C.,Kaplan, Joshua,Richard, David J.,Toral-Barza, Lourdes,Hollander, Irwin,Lucas, Judy,Ayral-Kaloustian, Semiramis,Yu, Ker,Zask, Arie. "Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent". scheme or table. p. 1440 - 1444. Retrieved 2010/07/06.