(1S,4R)-Methyl 4-aminocyclopent-2-enecarboxylate hydrochloride ,99% [ee:99%]

Base Information

• Chemical Name: (1S,4R)-Methyl 4-aminocyclopent-2-enecarboxylate hydrochloride ,99% [ee:99%]
• CAS No.: 77745-25-6
• Molecular Formula: C7H11NO2.HCl
• Molecular Weight: 177.63
• Mol file: 77745-25-6.mol

Synonyms:(1S,4R)-Methyl-4-aminocyclopentyl-2-enecarboxylate Hydrochloride;

Chemical Property of (1S,4R)-Methyl 4-aminocyclopent-2-enecarboxylate hydrochloride ,99% [ee:99%]

Chemical Property:

• PSA: 52.32000
• LogP: 1.56510

Purity/Quality:

99%min ^*data from raw suppliers

(1S,4R)-Methyl-4-aminocyclopentyl-2-enecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1S, 4R)-Methyl-4-aminocyclopentyl-2-enecarboxylate Hydrochloride is used to prepare fluorinated conformationally restricted analogues of GABA receptors, that have therapeutic applications for neurolo gical diseases. (1S, 4R)-Methyl-4-aminocyclopentyl-2-enecarboxylate Hydrochloride is used to prepare fluorinated conformationally restricted analogues of GABA receptors, that have therapeutic applications for neurological diseases.

Technology Process of (1S,4R)-Methyl 4-aminocyclopent-2-enecarboxylate hydrochloride ,99% [ee:99%]

There total 4 articles about (1S,4R)-Methyl 4-aminocyclopent-2-enecarboxylate hydrochloride ,99% [ee:99%] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride (61865-62-1) → cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride (77745-25-6,426226-35-9)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.1021/jo00329a026

Reference yield: 89.0%

methanol (67-56-1) + 2-azabicyclo[2.2.1.]hept-5-en-3-one (49805-30-3) → cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride (77745-25-6,426226-35-9)

Guidance literature:

With hydrogenchloride; for 22h; Heating;

DOI:10.1016/j.bmc.2005.11.010

Reference yield:

methanol (67-56-1) + racemic 2-azabicyclo[2.2.1]hept-5-en-3-one (49805-30-3) → cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride (77745-25-6,426226-35-9)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1016/0223-5234(89)90086-X

upstream raw materials:

methanol

racemic 2-azabicyclo[2.2.1]hept-5-en-3-one

cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride

2-azabicyclo[2.2.1.]hept-5-en-3-one

Downstream raw materials:

trans-4-Acetamidocyclopent-2-enemethyl Acetate

(+/-)-(1RS,4SR)acetic acid 4-acetylamido-cyclopent-2-enyl-methyl ester

(1β,2β,3α,5α)-5-Amino-3-hydroxymethyl-1,2-cyclopentanediol

(-)-(1R,2R,3S,4R)-4-amino-2,3-dihydroxy-1-(hydroxymethyl)cyclopentane

Refernces

• 1、 Migliore, Marco D.,Zonta, Nicola,McGuigan, Christopher,Henson, Geoffrey,Andrei, Graciela,Snoeck, Robert,Balzarini, Jan. "Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines". . p. 6485 - 6492. Retrieved 2008/03/27.
• 2、 Ikbal,Cerceau,Le Goffic,Sicsic. "Synthesis of the two enantiomers of the carbocyclic analog of nicotinamide ribose and analysis of their biological properties". . p. 415 - 420. Retrieved 2007/10/02.