(1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: (1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 61865-62-1
• Molecular Formula: C6H9NO2.ClH
• Molecular Weight: 0
• Hs Code.: 2922499990
• Mol file: 61865-62-1.mol

Synonyms:(1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE;(1S,4R)-4-aMinocyclopent-2-enecarboxylic acid-HCl

Chemical Property of (1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 63.32000
• LogP: 1.47670

Purity/Quality:

90% ^*data from raw suppliers

(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE

There total 1 articles about (1S,4R)-4-AMINO-CYCLOPENT-2-ENECARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-azabicyclo[2.2.1.]hept-5-en-3-one (49805-30-3) → cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride (61865-62-1)

Guidance literature:

With hydrogenchloride; water; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201201565

Reference yield: 98.0%

methanol (67-56-1) + cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride (61865-62-1) → cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride (77745-25-6,426226-35-9)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.1021/jo00329a026

Reference yield:

cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride (61865-62-1) → (1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid (151907-79-8,108999-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 3 h / 20 °C

1.2: pH 3 / Acidic conditions

2.1: (R)-1-phenyl-ethyl-amine / hexane; chloroform / Resolution of racemate

With (R)-1-phenyl-ethyl-amine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; hexane; chloroform; water;

DOI:10.1002/ejoc.201201565

upstream raw materials:

2-azabicyclo[2.2.1.]hept-5-en-3-one

Downstream raw materials:

cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride

(±)-4-aminocyclopent-1-enecarboxylic acid

(+/-)-(1RS,4SR)acetic acid 4-acetylamido-cyclopent-2-enyl-methyl ester

trans-4-Acetamidocyclopent-2-enemethyl Acetate

Refernces

• 1、 Kam, Bernard L.,Oppenheimer, Norman J.. "Carbocyclic Sugar Amines: Synthesis and Stereochemistry of Racemic α- and β-Carbocyclic Ribofuranosylamine, Carbocyclic Lyxofuranosylamine, and Related Compounds". . p. 3268 - 3272. Retrieved 2007/10/02.