Levmetamfetamine

Base Information

• Chemical Name: Levmetamfetamine
• CAS No.: 33817-09-3
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Hs Code.: 2921490002
• European Community (EC) Number: 251-687-0
• NSC Number: 6084
• UNII: Y24T9BT2Q2
• DSSTox Substance ID: DTXSID30187474
• Nikkaji Number: J50.041K
• Wikipedia: Levomethamphetamine
• Wikidata: Q402846
• NCI Thesaurus Code: C75930
• Pharos Ligand ID: MYD36HB131R3
• Metabolomics Workbench ID: 152428
• ChEMBL ID: CHEMBL1927030
• Mol file: 33817-09-3.mol

Synonyms:Levmetamfetamine;L-Methamphetamine;33817-09-3;l-Methylamphetamine;(-)-Methamphetamine;levomethamphetamine;(-)-Deoxyephedrine;R(-)-N-Methylamphetamine;l-1-Phenyl-2-methylaminopropane;Vicks;NSC 6084;Levmetamfetamine cii;(R)-Deoxyephedrine;(R)-N-Methyl-1-phenylpropan-2-amine;(-)-Methyl(alpha-methylphenethyl)amine;(R)-Methylamphetamine;l-1-Phenyl-2-methylamino-propan;L-DESOXYEPHEDRINE;EINECS 251-687-0;UNII-Y24T9BT2Q2;Levmetamfetamine [USAN:INN];l-1-Phenyl-2-methylamino-propan [German];Levmetamfetamine (in methanol);Y24T9BT2Q2;Benzeneethanamine, N,alpha-dimethyl-, (-)-;Benzeneethanamine, N,alpha-dimethyl-, (R)-;CHEMBL1927030;Benzeneethanamine, N,.alpha.-dimethyl-, (R)-;PHENETHYLAMINE, N,alpha-DIMETHYL-, (-)-;Levmetamfetamine [USAN:USP:INN];(r)-methamphetamine;(-)-(R)-N,alpha-Dimethylphenethylamine;(-)-(R)-N,.alpha.-Dimethylphenethylamine;(2R)-N-methyl-1-phenylpropan-2-amine;C10H15N;Vicks Inhaler;Phenethylamine, N,.alpha.-dimethyl-, D-;r(-)-methamphetamine;Methyl-((R)-1-methyl-2-phenyl-ethyl;l-(-)-Methamphetamine;1-METHAMPHETAMINE;Levmetamfetamine [USAN];(R)-N-Methylamphetamine;(-)-N-Methylamphetamine;2R-(-)-Methamphetamine;NCGC00247704-01;(R)-(-)-Deoxyephedrine;(R)-(-)-Methamphetamine;R-(-)-N-Methylamphetamine;Levmetamfetamine (USP/INN);LEVMETAMFETAMINE [INN];SCHEMBL727412;LEVMETAMFETAMINE [MART.];DTXSID30187474;LEVMETAMFETAMINE [WHO-DD];NSC6084;CHEBI:136013;NSC-6084;BDBM50359500;LEVMETAMFETAMINE CII [USP-RS];AKOS015962949;Phenethylamine,.alpha.-dimethyl-, D-;DB09571;LEVMETAMFETAMINE [USP IMPURITY];(-)-Deoxyephedrine, analytical standard;(2R)-N-methyl-1-phenyl-2-propanamine;LEVMETAMFETAMINE [USP MONOGRAPH];(-)-2--(Methyl-amino)-1-phenylpropane;AC-18760;N-Methyl-1-phenyl-2-propanamine, (-)-;Phenethylamine,.alpha.-dimethyl-, (-)-;Benzeneethanamine,.alpha.-dimethyl-, (-)-;Benzeneethanamine,.alpha.-dimethyl-, (R)-;LS-103330;Phenethylamine, N,.alpha.-dimethyl-, (-)-;Benzeneethanamine, N,.alpha.-dimethyl-, (-)-;D02291;benzeneethanamine, N,alpha-dimethyl-, (alphaR)-;Phenethylamine, N,alpha-dimethyl-, (-)- (8CI);Q402846;Benzeneethanamine, N,.alpha.-dimethyl-, (.alpha.R)-;Levmetamfetamine, United States Pharmacopeia (USP) Reference Standard

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Levmetamfetamine

Chemical Property:

• Vapor Pressure: 0.147mmHg at 25°C
• Melting Point: 38-40 °C
• Refractive Index: 1.503
• Boiling Point: 215.533 °C at 760 mmHg
• PKA: pKa 9.99(H2O,t =25±0.5,I=0.01)(Approximate)
• Flash Point: 86.781 °C
• PSA: 12.03000
• Density: 0.907 g/cm³
• LogP: 2.22790
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 95

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,F
• Statements: 23/24/25-63-36-39/23/24/25-11
• Safety Statements: 23-36/37/39-45-36/37-26-16-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)NC
• Isomeric SMILES: C[C@H](CC1=CC=CC=C1)NC
• Recent ClinicalTrials: Steady State Kinetics of l-Methamphetamine and Validation of Sensitivity of Dose Estimation

Technology Process of Levmetamfetamine

There total 44 articles about Levmetamfetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C12H15NO2 → (R)-2-methylamino-1-phenylpropane (33817-09-3)

Guidance literature:

C₁₂H₁₅NO₂; With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; for 3h; Large scale;

With sodium hydroxide; at 50 ℃; Large scale;

Reference yield: 96.7%

(R)-N-methyl-N-(1-methyl-2-oxo-2-phenyl)benzamide (171337-01-2) → (R)-2-methylamino-1-phenylpropane (33817-09-3)

Guidance literature:

With zinc amalgam; potassium hydroxide; In dichloromethane; at 50 ℃;

Reference yield: 95.0%

C12H12F3NO2 → (R)-2-methylamino-1-phenylpropane (33817-09-3)

Guidance literature:

With hydrazine hydrate; sodium hydroxide; at 50 ℃;

upstream raw materials:

methamphetamin

(1R,1'R)-N-2'-hydroxy-1'-phenylethyl-1-N-dimethyl-2-phenylethylamine

(+)-(1S,2R)-ephedrine hydrochloride

(-)-Pseudoephedrine hydrochloride

Downstream raw materials:

(R)-2-methylamino-1-cyclohexyl-propane

2-[methyl-((R)-1-methyl-2-phenyl-ethyl)-amino]-ethanol

SELEGILINE

3-((S)-1-(dimethylamino)ethyl)phenyl methyl-((R)-1-phenylpropan-2 yl)carbamate

Refernces

• 1、 -. "Preparation method of selegiline". Paragraph 0065; 0068; 0071. . Retrieved 2019/08/14.
• 2、 Navarro-Sánchez, José,Argente-García, Ana I.,Moliner-Martínez, Yolanda,Roca-Sanjuán, Daniel,Antypov, Dmytro,Campíns-Falcó, Pilar,Rosseinsky, Matthew J.,Martí-Gastaldo, Carlos. "Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs". . p. 4294 - 4297. Retrieved 2017/04/03.