4-AMINOMETHYL-1-N-CBZ-PIPERIDINE HCL

Base Information

• Chemical Name: 4-AMINOMETHYL-1-N-CBZ-PIPERIDINE HCL
• CAS No.: 172348-57-1
• Molecular Formula: C14H21ClN2O2
• Molecular Weight: 284.78174
• Hs Code.: 2933399090
• Mol file: 172348-57-1.mol

Synonyms:4-Aminomethyl-1-N-Cbz-piperidine hydrochloride;4-Aminomethyl-piperidine-1-carboxylic acid benzyl ester hydrochloride;

Chemical Property of 4-AMINOMETHYL-1-N-CBZ-PIPERIDINE HCL

Chemical Property:

• Vapor Pressure: 2.88E-07mmHg at 25°C
• Boiling Point: 414.4°C at 760 mmHg
• Flash Point: 204.4°C
• PSA: 55.56000
• LogP: 3.43410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Benzyl4-(aminomethyl)piperidine-1-carboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINOMETHYL-1-N-CBZ-PIPERIDINE HCL

There total 2 articles about 4-AMINOMETHYL-1-N-CBZ-PIPERIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate (172348-56-0) → [1-(benzyloxycarbonyl)-4-piperidyl] methylamine hydrochloride (172348-57-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

4-aminomethyl-piperidine-1-carboxylic acid benzyl ester (157023-34-2) → [1-(benzyloxycarbonyl)-4-piperidyl] methylamine hydrochloride (172348-57-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethyl acetate; Cooling with ice;

Reference yield: 86.0%

3-phenylpyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (889654-10-8) + [1-(benzyloxycarbonyl)-4-piperidyl] methylamine hydrochloride (172348-57-1) → benzyl 4-((1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-3-carboxamido)methyl)piperidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

4-aminomethyl-piperidine-1-carboxylic acid benzyl ester

benzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate

Refernces

• 1、 -. "N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE AND USE THEREOF AS TNF-γ(a) PRODUCTION INHIBITOR". Page 10. . Retrieved 2008/06/13.