9H-Fluoren-9-ylideneacetic acid

Base Information

• Chemical Name: 9H-Fluoren-9-ylideneacetic acid
• CAS No.: 4425-73-4
• Molecular Formula: C15H9O2-
• Molecular Weight: 222.243
• Hs Code.: 2916399090
• European Community (EC) Number: 224-604-0
• NSC Number: 89573
• DSSTox Substance ID: DTXSID50963196
• Nikkaji Number: J205.802B
• Mol file: 4425-73-4.mol

Synonyms:4425-73-4;9-FLUORENYLIDENEACETIC ACID;9H-Fluoren-9-ylideneacetic acid;2-(9H-fluoren-9-ylidene)acetic acid;2-fluoren-9-ylideneacetic acid;Acetic acid, 9H-fluoren-9-ylidene-;EINECS 224-604-0;Biphenylenecrylic acid;9-fluorenylidene acetic acid;fluoren-9-ylidene-acetic acid;SCHEMBL130160;Acetic acid, 9-fluorenylidene-;DTXSID50963196;9H-Fluorene-9-ylideneacetic acid;(9H-Fluoren-9-ylidene)acetic acid;9H-Fluoren-9-ylideneacetic acid #;NSC89573;2-(9H-fluoren-9-ylidene)aceticacid;MFCD00040930;NSC 89573;NSC-89573;AKOS022887069;CS-0358792;FT-0635286

Chemical Property of 9H-Fluoren-9-ylideneacetic acid

Chemical Property:

• Vapor Pressure: 1.22E-06mmHg at 25°C
• Melting Point: 231-233oC
• Boiling Point: 385.7°Cat760mmHg
• Flash Point: 284.1°C
• PSA: 37.30000
• Density: 1.387g/cm³
• LogP: 3.18330
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 222.068079557
• Heavy Atom Count: 17
• Complexity: 321

Purity/Quality:

99% ^*data from raw suppliers

9H-Fluoren-9-ylideneacetic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3C2=CC(=O)O

Technology Process of 9H-Fluoren-9-ylideneacetic acid

There total 15 articles about 9H-Fluoren-9-ylideneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dibenzofulvenecarboxylic acid ethyl ester (27973-36-0) → fluoren-9-ylidene-acetic acid (4425-73-4)

Guidance literature:

With sodium hydroxide; ethanol; water; at 60 ℃; for 0.75h;

Reference yield:

2-(9H-fluoren-9-ylidene)acetaldehyde (4425-71-2) → fluoren-9-ylidene-acetic acid (4425-73-4)

Guidance literature:

With silver(l) oxide;

DOI:10.1021/ja01617a031

Reference yield:

9-ethynylfluoren-9-ol (13461-74-0) → fluoren-9-ylidene-acetic acid (4425-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic H₂SO₄

2: Ag₂O

With sulfuric acid; silver(l) oxide;

DOI:10.1021/ja01617a031

upstream raw materials:

9-fluorenone

2-(9H-fluoren-9-ylidene)acetaldehyde

ethyl 2-(9H-fluoren-9-yl)-2-hydroxyacetate

sodium ethanolate

Downstream raw materials:

3-{4-[2-(2-Fluoren-9-ylidene-acetylamino)-ethyl]-phenyl}-propionic acid ethyl ester

3-{4-[2-(2-Fluoren-9-ylidene-acetylamino)-ethyl]-phenyl}-propionic acid

(R)-N-(2-(9H-fluoren-9-ylidene)ethyl)-1-(4-fluorophenyl)ethanamine

(R)-N-(2-(9H-fluoren-9-ylidene)ethyl)-1-(4-fluorophenyl)ethanamine

Refernces

• 1、 -. "UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF". Page/Page column 66. . Retrieved 2010/11/24.
• 2、 Nishino, Hiroshi. "Reaction of Olefins with Malonamide in the Presence of Manganese(III) Acetate. Formation of α,β-Unsaturated γ-Lactones and γ-Lactams". . p. 217 - 222. Retrieved 2007/10/02.