Methyl 2-chloro-6-fluorobenzoate

Base Information

• Chemical Name: Methyl 2-chloro-6-fluorobenzoate
• CAS No.: 151360-57-5
• Molecular Formula: C8H6ClFO2
• Molecular Weight: 188.5834
• Hs Code.: 2916399090
• Mol file: 151360-57-5.mol

Synonyms:benzoic acid, 2-chloro-6-fluoro-, methyl ester

Chemical Property of Methyl 2-chloro-6-fluorobenzoate

Chemical Property:

• Vapor Pressure: 0.053mmHg at 25°C
• Boiling Point: 234.4°C at 760 mmHg
• Flash Point: 99.9°C
• PSA: 26.30000
• Density: 1.314g/cm³
• LogP: 2.26570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

methyl2-chloro-6-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloro-6-fluorobenzoate

There total 4 articles about Methyl 2-chloro-6-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methanol (67-56-1) + 2-chloro-6-fluorobenzoic acid (434-75-3) → methyl 2-chloro-6-fluorobenzoate (151360-57-5)

Guidance literature:

With sulfuric acid; at 110 ℃; for 3h; Microwave irradiation;

Reference yield:

3-chlorofluorobenzene (625-98-9) + methyl chloroformate (79-22-1) → methyl 2-chloro-6-fluorobenzoate (151360-57-5)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

methyl chloroformate; In tetrahydrofuran; at -78 - 23 ℃;

DOI:10.1016/j.bmcl.2008.07.111

Reference yield:

methyl chloroformate (79-22-1) → methyl 2-chloro-6-fluorobenzoate (151360-57-5)

Guidance literature:

3-chlorofluorobenzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 2.16667h;

methyl chloroformate; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 3h;

With water; In tetrahydrofuran; hexanes;

upstream raw materials:

methyl chloroformate

diethyl ether

2-chloro-6-fluorobenzoic acid

3-chlorofluorobenzene

Downstream raw materials:

3-(2-chloro-6-fluorophenyl)-3-oxopropanenitrile

2-(2-chloro-6-fluorophenyl)pyrrolidine

Refernces

• 1、 -. "DI-AMINO-SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE". Page/Page column 31. . Retrieved 2008/06/13.
• 2、 -. "Heterocyclic compounds and methods of use". Page/Page column 14; 15. . Retrieved 2008/12/07.