2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-

Base Information

• Chemical Name: 2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-
• CAS No.: 944898-52-6
• Molecular Formula: C8H4BrNO3
• Molecular Weight: 242.03
• Hs Code.: 2934999090
• Mol file: 944898-52-6.mol

Synonyms:5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID;2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-;5-BROMO-1,3-BENZOXAZOLE-2-CARBOXYLIC ACID;

Chemical Property of 2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-

Chemical Property:

• PSA: 63.33000
• LogP: 2.28850

Purity/Quality:

98%Min ^*data from raw suppliers

5-Bromo-1,3-benzoxazole-2-carboxylic acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-

There total 1 articles about 2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-1,3-benzoxazole (132244-31-6) + carbon dioxide (124-38-9,18923-20-1) → 5-bromo-1,3-benzoxazole-2-carboxylic acid (944898-52-6)

Guidance literature:

With C₂₇H₃₇ClCuN₃; potassium tert-butylate; In tetrahydrofuran; at 80 ℃; for 8h; under 760.051 Torr; Inert atmosphere; sealed tube;

DOI:10.1021/ol301760n

Reference yield:

5-bromo-1,3-benzoxazole-2-carboxylic acid (944898-52-6) + (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride (1448189-80-7,2115897-23-7) → 5-bromo-N-{(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl}-1,3-benzoxazole-2-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 17h; Cooling with ice;

Reference yield:

5-bromo-1,3-benzoxazole-2-carboxylic acid (944898-52-6) + methyl iodide (74-88-4) → 5-bromo-benzoxazole-2-carboxylic acid methyl ester (954239-61-3)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere; sealed tube;

DOI:10.1021/ol301760n

upstream raw materials:

5-bromo-1,3-benzoxazole

carbon dioxide

Downstream raw materials:

5-bromo-benzoxazole-2-carboxylic acid methyl ester

Refernces