Oxazole, 2-bromo-4-methyl-

Base Information

• Chemical Name: Oxazole, 2-bromo-4-methyl-
• CAS No.: 1060816-11-6
• Molecular Formula: C4H4BrNO
• Molecular Weight: 162
• Hs Code.: 2934999090
• Mol file: 1060816-11-6.mol

Synonyms:2-methyl oxazole 4-ethyl ester

Chemical Property of Oxazole, 2-bromo-4-methyl-

Chemical Property:

• Appearance/Colour: Brown to grey crystalline powder
• Boiling Point: 188.7±33.0 °C(Predicted)
• PKA: -0.22±0.10(Predicted)
• PSA: 26.03000
• Density: 1.654±0.06 g/cm3(Predicted)
• LogP: 1.74550

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-methyloxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazole, 2-bromo-4-methyl-

There total 1 articles about Oxazole, 2-bromo-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-methyloxazole (693-93-6) → 2-bromo-4-methyloxazole (1060816-11-6)

Guidance literature:

4-methyloxazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; In tetrahydrofuran; hexane; at -78 - 25 ℃; regioselective reaction;

DOI:10.1002/ejoc.201900032

Reference yield:

2-bromo-4-methyloxazole (1060816-11-6) + C22H34N2O2 → (R)-2-methyl-1-(2-(1-(2-(4-methyloxazol-2-yl)-2-azaspiro[3.4]octan-6-yl)piperidin-4-yl)phenoxy)propan-2-ol

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 75 ℃; for 16h; Inert atmosphere;

Reference yield:

2-bromo-4-methyloxazole (1060816-11-6) + C22H33FN2O2 → (R)-1-(5-fluoro-2-(1-(2-(4-methyloxazol-2-yl)-2-azaspiro[3.4]octan-6-yl)piperidin-4-yl)phenoxy)-2-methylpropan-2-ol

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 75 ℃; for 2.5h; Inert atmosphere;

upstream raw materials:

4-methyloxazole

Refernces