tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate

Base Information

• Chemical Name: tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate
• CAS No.: 1032349-98-6
• Molecular Formula: C23H27NO3
• Molecular Weight: 365.472
• Hs Code.: 2924299090
• Mol file: 1032349-98-6.mol

Synonyms:tert-Butyl [1-[4-(phenylacetyl)phenyl]cyclobutyl]carbamate;tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate;tert-butyl N-[1-[4-(2-phenylacetyl)phenyl]cyclobutyl]carbamate;Carbamic acid, N-[1-[4-(2-phenylacetyl)phenyl]cyclobutyl]-, 1,1-dimethylethyl ester

Chemical Property of tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate

Chemical Property:

• PSA: 58.89000
• LogP: 5.22030

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(1-(4-(2-phenylacetyl)phenyl)cyclobutyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate

There total 4 articles about tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate (1032349-97-5) + benzylmagnesium chloride (6921-34-2) → tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate (1032349-98-6)

Guidance literature:

tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate; benzylmagnesium chloride; In tetrahydrofuran; at -78 - 25 ℃; Inert atmosphere;

With sodium hydrogencarbonate; ammonium chloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jm201394e

Reference yield:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate (1032349-96-4) → tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate (1032349-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm201394e

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate (1032349-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 18 h / 60 °C / Inert atmosphere

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C

3.3: 0 °C

With sodium azide; tetrabutylammomium bromide; isopropylmagnesium chloride; zinc trifluoromethanesulfonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1.1: Curtius Rearrangement;

upstream raw materials:

tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate

benzylmagnesium chloride

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl {1-[4-(5-chloro-3-phenyl-1,6-naphthyrindin-2-yl)phenyl]cyclobutyl}carbamate

2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

tert-butyl 1-(4-(2-(2-formyl-1H-pyrrol-1-yl)-2-phenylacetyl)phenyl)cyclobutylcarbamate

tert-butyl 1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutylcarbamate

Refernces

• 1、 -. "INHIBITORS OF AKT ACTIVITY". Page/Page column 80. . Retrieved 2010/08/09.
• 2、 -. "Inhibitors of Akt activity". Page/Page column 31. . Retrieved 2008/12/06.