tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate
• CAS No.: 1032349-97-5
• Molecular Formula: C16H20N2O2
• Molecular Weight: 272.347
• Hs Code.: 2926909090
• Mol file: 1032349-97-5.mol

Synonyms:tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate;CarbaMic acid, N-[1-(4-cyanophenyl)cyclobutyl]-, 1,1-diMethylethyl ester

Chemical Property of tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate

Chemical Property:

• PSA: 65.61000
• Density: 1.13
• LogP: 3.66658
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl1-(4-Cyanophenyl)cyclobutylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate

There total 5 articles about tert-butyl 1-(4-cyanophenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

zinc(II) cyanide (557-21-1) + tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate (1032349-96-4) → tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate (1032349-97-5)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm201394e

Reference yield:

zinc(II) cyanide (557-21-1) + tert-butyl [1-(4-bromophenyl)cyclobutyl] carbamate → tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate (1032349-97-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl-formamide; at 92 - 95 ℃; for 4h;

Reference yield:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate (1032349-96-4) + dicyanozinc (557-21-1) → tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate (1032349-97-5)

Guidance literature:

bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 1.5h; Product distribution / selectivity;

upstream raw materials:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

dicyanozinc

zinc(II) cyanide

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

tert-butyl {1-[4-(5-chloro-3-phenyl-1,6-naphthyrindin-2-yl)phenyl]cyclobutyl}carbamate

1-[4-(1-methyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl)phenyl]cyclobutanamine

7-[4-(1-aminocyclobutyl)phenyl]-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthylidin-1-amine

Refernces

• 1、 Kettle, Jason G.,Brown, Simon,Crafter, Claire,Davies, Barry R.,Dudley, Phillippa,Fairley, Gary,Faulder, Paul,Fillery, Shaun,Greenwood, Hannah,Hawkins, Janet,James, Michael,Johnson, Keith,Lane, Clare D.,Pass, Martin,Pink, Jennifer H.,Plant, Helen,Cosulich, Sabina C.. "Diverse heterocyclic scaffolds as allosteric inhibitors of AKT". supporting information; experimental part. p. 1261 - 1273. Retrieved 2012/04/10.
• 2、 -. "INHIBITORS OF AKT ACTIVITY". Page/Page column 50. . Retrieved 2009/12/28.