Larotaxel

Base Information Edit

Chemical Name:Larotaxel
CAS No.:156294-36-9
Molecular Formula:C45H53NO14
Molecular Weight:831.914
Hs Code.:
European Community (EC) Number:682-335-8
UNII:TWQ8K8A81Y
Nikkaji Number:J912.846H
Wikipedia:Larotaxel
Wikidata:Q6489757
NCI Thesaurus Code:C48427
Metabolomics Workbench ID:153866
ChEMBL ID:CHEMBL4279455
Mol file:156294-36-9.mol

Synonyms:larotaxel;XRP 9881;XRP-9881;XRP9881

Suppliers and Price of Larotaxel

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Larotaxel
10mg
$ 400.00

Total 18 raw suppliers

Chemical Property of Larotaxel Edit

Chemical Property:

Boiling Point:889.3±65.0 °C(Predicted)
PKA:11.20±0.46(Predicted)
PSA：213.78000
Density:1.37
LogP:4.67390
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:15
Exact Mass:831.34660536
Heavy Atom Count:60
Complexity:1790

Purity/Quality:

98%Min ^*data from raw suppliers

Larotaxel ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(C(=O)C34CC3CC5C(C4C(C(C2(C)C)(CC1OC(=O)C(C(C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C
Isomeric SMILES:CC1=C2[C@H](C(=O)[C@]34C[C@H]3C[C@@H]5[C@]([C@H]4[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C
Recent ClinicalTrials:Larotaxel Compared To Continuous Administration of 5-FU in Advanced Pancreatic Cancer Patients Previously Treated With A Gemcitabine-Containing Regimen
Recent EU Clinical Trials:Randomized Study of LAROTAXEL + Cisplatin (LC) vs. Gemcitabine + Cisplatin (GC) in the First Line Treatment of Locally Advanced/Metastatic Urothelial Tract or Bladder Cancer
Uses Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS.

Technology Process of Larotaxel

There total 13 articles about Larotaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₁H₆₇NO₁₄Si

: 156294-36-9
7-deoxy-7β, 8β-methylene-10-O-acetyldocetaxel

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 40 ℃; for 3h; pH=7;
DOI:10.1016/j.ejmech.2018.07.029

Reference yield:

: 156294-35-8
(2α,3α,4α,5β,7α,10β,13α)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-9-oxo-5,20-epoxy-7,19-cyclotax-11-en-2-yl benzoate

: 156294-36-9
7-deoxy-7β, 8β-methylene-10-O-acetyldocetaxel

Guidance literature:: With hydrogenchloride; In methanol; water; at 0 - 5 ℃; for 2.5h;

Reference yield:

: 158811-19-9
10-acetyl-7-trifluoromethanesulfonate baccatin III

: 156294-36-9
7-deoxy-7β, 8β-methylene-10-O-acetyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / acetonitrile / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -15 - 5 °C / Inert atmosphere

2.2: 1 h / -5 - 5 °C / Inert atmosphere

2.3: 1.5 h / Inert atmosphere

3.1: hydrogenchloride / water; methanol / 2.5 h / 0 - 5 °C

With hydrogenchloride; sodium azide; sodium hydride; In tetrahydrofuran; methanol; water; acetonitrile; mineral oil;