Technology Process of 3H,5H-2,23:5,8-Dimethano-1H-4,13,2,8,11-benzodioxatriazacycloheneicosine-7-carboxylic acid, 10-(1,1-dimethylethyl)-6,7,9,10,11,12,14,15,16,17,18,19-dodecahydro-15,15-dimethyl-3,9,12-trioxo-, methyl ester, (5R,7S,10S)-
There total 23 articles about 3H,5H-2,23:5,8-Dimethano-1H-4,13,2,8,11-benzodioxatriazacycloheneicosine-7-carboxylic acid, 10-(1,1-dimethylethyl)-6,7,9,10,11,12,14,15,16,17,18,19-dodecahydro-15,15-dimethyl-3,9,12-trioxo-, methyl ester, (5R,7S,10S)- which
guide to synthetic route it.
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synthetic route:
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923591-06-4
methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate
- Guidance literature:
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With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
for 18h;
DOI:10.1021/acs.joc.7b01308
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923591-06-4
methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate
- Guidance literature:
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1-benzyl 2-methyl (2S,4R)-4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate; C12H23N*C15H27NO4;
With
palladium diacetate;
In
1-methyl-pyrrolidin-2-one;
at 100 ℃;
for 2h;
Inert atmosphere;
With
palladium 10% on activated carbon; hydrogen;
In
1-methyl-pyrrolidin-2-one;
under 2828.7 Torr;
With
2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo2011494
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923591-03-1
methyl (1R,12E,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]-heptacosa-6,8,10,12-tetraene-24-carboxylate
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923591-06-4
methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate
- Guidance literature:
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With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 17h;