1-(5-bromo-2-fluorophenyl)propan-1-ol

Base Information

• Chemical Name: 1-(5-bromo-2-fluorophenyl)propan-1-ol
• CAS No.: 1197943-64-8
• Molecular Formula: C9H10BrFO
• Molecular Weight: 233.0775032
• Mol file: 1197943-64-8.mol

Synonyms:1-(5-bromo-2-fluorophenyl)propan-1-ol

Chemical Property of 1-(5-bromo-2-fluorophenyl)propan-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 3.03160

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Bromo-2-fluorophenyl)propan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-bromo-2-fluorophenyl)propan-1-ol

There total 1 articles about 1-(5-bromo-2-fluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethylmagnesium bromide (925-90-6) + 5-bromo-2-fluorobenzaldehyde (93777-26-5) → 1-(5-bromo-2-fluorophenyl)propan-1-ol (1197943-64-8)

Guidance literature:

ethylmagnesium bromide; 5-bromo-2-fluorobenzaldehyde; In diethyl ether; at 15 - 20 ℃;

With water; ammonium chloride; In diethyl ether; Cooling;

Reference yield:

1-(5-bromo-2-fluorophenyl)propan-1-ol (1197943-64-8) → 5-bromo-3-ethyl-1H-indazole (864774-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dioxane / 4 h / Heating

2: hydrazine monohydrate / 9 h / Heating

With manganese(IV) oxide; hydrazine hydrate; In 1,4-dioxane;

DOI:10.1016/j.bmc.2006.06.047

Reference yield:

1-(5-bromo-2-fluorophenyl)propan-1-ol (1197943-64-8) → (3-ethyl-1H-indazol-5-yl)(5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl)methanol

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: hydrazine hydrate / dichloromethane / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

3.2: 1 h / -78 °C

3.3: 2 h / -40 °C

With n-butyllithium; hydrazine hydrate; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

ethylmagnesium bromide

5-bromo-2-fluorobenzaldehyde

Downstream raw materials:

5-bromo-3-ethyl-1H-indazole

Refernces

• 1、 -. "INDAZOLYL-SUBSTITUTED DIHYDROISOXA-ZOLOPYRIDINES AND METHODS OF USE THEREOF". Page/Page column 46. . Retrieved 2011/02/24.
• 2、 -. "FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF". Page/Page column 36. . Retrieved 2011/04/26.