93777-26-5

Basic information

• Product Name: 5-Bromo-2-fluorobenzaldehyde
• Synonyms: LABOTEST-BB LT01143303;2-FLUORO-5-BROMOBENZALDEHYDE;5-BROMO-2-FLUOROBENZALDEHYDE;AKOS BBS-00003261;5-Bromo-2-Fluorobenzaldehyde 2-Fluoro-5-Bromobenzaldehyde;5-Bromo-2-fluorobenzaldehyde 98%;5-Bromo-2-fluorobenzaldehyde98%;Benzaldehyde, 5-bromo-2-fluoro-
• CAS NO: 93777-26-5
• Molecular Formula: C₇H₄BrFO
• Molecular Weight: 203.01
• EINECS: 298-056-6
• Product Categories: Fluorin-contained benzaldehyde series;Carbonyl Compounds;Halides;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;API intermediates;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Aldehydes;C7;Carbonyl Compounds;Benzaldehyde series
• Mol File: 93777-26-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 230 °C(lit.)
• Flash Point: 229 °F
• Appearance: clear yellowish liquid after melting
• Density: 1.71 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0603mmHg at 25°C
• Refractive Index: n20/D 1.57(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: INSOLUBLE
• Sensitive: Air Sensitive
• BRN: 7632798
• CAS DataBase Reference: 5-Bromo-2-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-fluorobenzaldehyde(93777-26-5)
• EPA Substance Registry System: 5-Bromo-2-fluorobenzaldehyde(93777-26-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 93777-26-5(Hazardous Substances Data)

Usage

Uses

5-Bromo-2-fluorobenzaldehyde is used for the preparation of benzimidazole derivatives as inhibitors of leukotriene production.

InChI:InChI=1/C9H8ClFO/c1-6(12)5-7-8(10)3-2-4-9(7)11/h2-4H,5H2,1H3

Upstream product

• 99725-12-9 4-bromo-2-(bromomethyl)-1-fluorobenzene 
• 221030-92-8 4-Bromo-1-fluoro-2-vinyl-benzene 
• 3132-99-8 m-bromobenzoic aldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 107-31-3 Methyl formate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 311808-51-2 5-bromo-2-[(2,4-dichlorophenyl)thio]benzaldehyde 
• 602326-08-9 5-bromo-2-(2,4-dibromophenoxy)benzaldehyde 
• 719297-11-7 tert-butyl 4-[(4-bromo-2-formylphenyl)(ethyl)amino]butanoate 
• 719297-12-8 tert-butyl 4-[(4-bromo-2-formylphenyl)(propyl)amino]butanoate 
• 460087-72-3 (5-Bromo-2-fluoro-phenyl)-(2-ethoxy-3,5-diisopropyl-phenyl)-methanol 
• 313737-28-9 4-(4-bromo-2-formyl-N-isopropylanilino)butyric acid 
• 854764-36-6 4-[(4-bromo-2-formyl-phenyl)-isobutyl-amino]-butyric acid 
• 897627-88-2 diethyl 4-(5-bromo-2-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate 
• 897627-89-3 di-tert-butyl 4-(5-bromo-2-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate 
• 7312-11-0 5-bromo-1-benzothiophene-2-carboxylic acid methyl ester 
• 679840-30-3 2-(5-bromo-2-fluorophenyl)-1,3-dioxolane 
• 679839-14-6 5-bromo-2-(cis-2,6-dimethylmorpholin-4-yl)benzaldehyde 
• 221030-92-8 4-Bromo-1-fluoro-2-vinyl-benzene 
• 445303-69-5 4-bromo-2-(difluoromethyl)-1-fluorobenzene 

Relevant articles and documents

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.

Preparation method of 2-fluoro-5-bromobenzaldehyde

The invention relates to a preparation method of 2-fluoro-5-bromobenzaldehyde as a medicine intermediate. O-fluorobenzaldehyde and a bromination reagent undergo a reaction in the presence of Lewis acid as a catalyst and the reaction product is subjected to reduced pressure distillation so that 2-fluoro-5-bromobenzaldehyde with a high yield and high content is obtained. The preparation method has the characteristics of easy availability of raw materials, less reaction processes, high yield and low cost.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.