221030-92-8

Basic information

• Product Name: 4-Bromo-1-fluoro-2-vinyl-benzene
• Synonyms: 4-Bromo-1-fluoro-2-vinyl-benzene
• CAS NO: 221030-92-8
• Molecular Weight: 201.038
• Mol File: 221030-92-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-Bromo-1-fluoro-2-vinyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-fluoro-2-vinyl-benzene(221030-92-8)
• EPA Substance Registry System: 4-Bromo-1-fluoro-2-vinyl-benzene(221030-92-8)

Safety Data

• Hazardous Substances Data: 221030-92-8(Hazardous Substances Data)

Upstream product

• 2065-66-9 methyl-triphenylphosphonium iodide 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 844904-33-2 (5-bromo-2-fluorophenyl)acetaldehyde 
• 627463-25-6 4-bromo-2-ethyl-1-fluoro-benzene 

Relevant articles and documents

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes

The copper(II)-promoted free-radical oxidative difunctionalization of terminal alkenes to access ketoazides by utilizing molecular oxygen has been reported. A series of styrene derivatives have been evaluated and were found to be compatible to give the desired difunctionalized products in moderate to good yields. The role of molecular oxygen both as an oxidant and oxygen atom source in this catalytic transformation has been unquestionably demonstrated by 18O-labeling studies and a radical mechanistic pathway involving the oxidative formation of azidyl radicals is also designed. This environment-friendly catalytic oxidative protocol can transform aldehyde to nitrile.

IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS

Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is (a) a radical of formula R1R2CHNH-Y-L1-X1-(CH2)Z- wherein: z is 0 or 1; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non- natural alpha amino acid; Y is a bond, -C(=O)-, -S(=O)2-, -C(=O)O-, -C(=O)NR3-, - C(=S)-NR3, -C(=NH)-NR3 or -S(=O)2NR3- wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent linker radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, AIk1 and AIk2 are as defined in the claims.