445303-69-5

Basic information

• Product Name: 4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE
• Synonyms: 4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE;4-BROMO-1-FLUORO-2-(DIFLUOROMETHYL)BENZENE;5-BROMO-2-FLUORO-1-(DIFLUOROMETHYL)BENZENE;4-BROMO-1-FLUORO-2-(DIFLUOROMETHYL)BENZENE, 97% MIN.;3-(Difluoromethyl)-4-fluoro-1-bromobenzene;4-Bromo-2-(difluoromethyl)-1-fluorobenzene 97+%;1-Bromo-4-fluoro-3-(difluoromethyl)benzene
• CAS NO: 445303-69-5
• Molecular Formula: C₇H₄BrF₃
• Molecular Weight: 225.01
• Product Categories: Fluorine series
• Mol File: 445303-69-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 188℃
• Flash Point: 75℃
• Appearance: /
• Density: 1.633
• Vapor Pressure: 0.838mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE(445303-69-5)
• EPA Substance Registry System: 4-BROMO-2-DIFLUOROMETHYL-1-FLUOROBENZENE(445303-69-5)

Safety Data

• Hazardous Substances Data: 445303-69-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-difluoromethyl-1-fluorobenzene is a chemical compound with the molecular formula C7H4BrF3. It is a colorless liquid with a molecular weight of 207.01 g/mol. 4-Bromo-2-difluoromethyl-1-fluorobenzene is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of fine chemicals and pharmaceuticals. 4-Bromo-2-difluoromethyl-1-fluorobenzene is considered to be a hazardous chemical and should be handled and stored with caution.

InChI:InChI=1/C7H4BrF3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,7H

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 445303-65-1 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 941711-20-2 4-[3-(difluoromethyl)-4-fluorophenyl]pyridine 

Relevant articles and documents

KINASE ANTAGONISTS AND METHODS FOR MAKING AND USING THEM

Disclosed herein are small molecule compounds that are SGK1 antagonists, formulations and pharmaceutical compositions comprising the compounds, and methods of making and using them, for treating, ameliorating, preventing, reversing or slowing the progression of: a cancer, a tumor, a metastasis or a dysplastic or a dysfunctional cell condition responsive to inhibition of a kinase enzyme of the AGC group of kinases including SGK1, by administration of an AGC kinase inhibitor or antagonist.

DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION

The present invention relates to compounds of the formulae (4), (5) or (6), and their use in the treatment of central nervous system disorders.

Imidazole derivatives

Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.