3-methoxy-2-Butenoic acid

Base Information

• Chemical Name: 3-methoxy-2-Butenoic acid
• CAS No.: 67107-76-0
• Molecular Formula: C5H8O3
• Molecular Weight: 116.117
• Mol file: 67107-76-0.mol

Synonyms:3-methoxy-2-Butenoic acid

Chemical Property of 3-methoxy-2-Butenoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 0.62120

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methoxy-2-Butenoic acid

There total 16 articles about 3-methoxy-2-Butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (E)-3-methoxybut-2-enoate (4525-28-4) → (E)-β-methoxymethacrylic acid (67107-76-0,156947-99-8,156948-00-4)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 0 - 70 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.202001216

Reference yield: 81.0%

(E)-1,1,1-trichloro-4-methoxypent-3-en-2-one (135351-18-7) → (E)-β-methoxymethacrylic acid (67107-76-0,156947-99-8,156948-00-4)

Guidance literature:

With sodium hydroxide; for 2.5h; Ambient temperature;

DOI:10.1002/jhet.5570340226

Reference yield: 80.0%

ethyl (2E)-3-methoxy-2-butenoate (22157-27-3) → (E)-β-methoxymethacrylic acid (67107-76-0,156947-99-8,156948-00-4)

Guidance literature:

With lithium hydroxide monohydrate; In water; at 67 ℃; for 24h;

upstream raw materials:

diazomethane

ethyl acetoacetate

3-methoxy-2(E)-butenoic acid ethyl ester

methanol

Downstream raw materials:

3-methoxy-2-butenoic acid

(R)-3-(methoxy)butanoic acid

C₅H₁₀O₃

3-(2,4-dinitro-phenylhydrazono)-butyric acid

Refernces

• 1、 Adair, Liam,Egan, Ben A.,Pearson, Colin M.,Lopez-Gonzalez, Ricardo,Kuchar, Michal,Mendoza-Mendoza, Artemio,Prunet, Jo?lle,Marquez, Rodolfo. "Isobenzofurans as Synthetic Intermediates: Synthesis and Biological Activity of 8-epi-(–)-Ajudazol B". supporting information. p. 6661 - 6672. Retrieved 2020/10/15.
• 2、 Essig, Sebastian,Bretzke, Sebastian,Müller, Rolf,Menche, Dirk. "Full stereochemical determination of ajudazols a and b by bioinformatics gene cluster analysis and total synthesis of ajudazol B by an asymmetric ortholithiation strategy". supporting information. p. 19362 - 19365. Retrieved 2013/02/21.