N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine

Base Information

• Chemical Name: N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine
• CAS No.: 1036378-89-8
• Molecular Formula: C11H16BrNO2
• Molecular Weight: 274.158
• Hs Code.: 2922199090
• Mol file: 1036378-89-8.mol

Synonyms:N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine;N-(4-broMobenzyl)-2,2-diMethoxyethaN/AMine

Chemical Property of N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine

Chemical Property:

• PSA: 30.49000
• LogP: 2.54850

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Bromobenzyl)-2,2-dimethoxyethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine

There total 3 articles about N-(4-BroMobenzyl)-2,2-diMethoxyethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

4-bromo-benzaldehyde (1122-91-4) + 2,2-dimethoxyethylamine (22483-09-6) → 2-(4-bromobenzylamino)acetaldehyde dimethyl aceta (1036378-89-8)

Guidance literature:

4-bromo-benzaldehyde; 2,2-dimethoxyethylamine; In ethanol; at 20 ℃; for 12h;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2016.04.031

Reference yield:

dimethyl(p-bromobenzylidene)aminoacetal (1009309-65-2) → 2-(4-bromobenzylamino)acetaldehyde dimethyl aceta (1036378-89-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 24h; Ambient temperature;

DOI:10.1021/jm00386a008

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 2-(4-bromobenzylamino)acetaldehyde dimethyl aceta (1036378-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.33 h / Heating

2: sodium borohydride / ethanol / 24 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00386a008

upstream raw materials:

dimethyl(p-bromobenzylidene)aminoacetal

4-bromo-benzaldehyde

2,2-dimethoxyethylamine

Downstream raw materials:

N-(4-bromo-benzyl)-N-(2,2-dimethoxy-ethyl)-4-methyl-benzenesulfonamide

6-bromo-2-tosyl-1,2,3,4-tetrahydroisoquinoline

6-bromo-isoquinoline

1-(4-Bromo-benzyl)-1,3-dihydro-imidazole-2-thione

Refernces

• 1、 Luu, Quang H.,Guerra, Jorge D.,Casta?eda, Cecilio M.,Martinez, Manuel A.,Saunders, Jong,Garcia, Benjamin A.,Gonzales, Brenda V.,Aidunuthula, Anushritha R.,Mito, Shizue. "Ultrasound assisted one-pot synthesis of benzo-fused indole-4,9-dinones from 1,4-naphthoquinone and α-aminoacetals". supporting information. p. 2253 - 2256. Retrieved 2016/05/10.
• 2、 -. "New substituted isoquinoline and isoquinolinone derivatives". Page/Page column 14. . Retrieved 2010/04/23.