4-Benzyloxy-3-Methoxy-phenylaMine HCl

Base Information

• Chemical Name: 4-Benzyloxy-3-Methoxy-phenylaMine HCl
• CAS No.: 1159825-08-7
• Molecular Formula: C14H15NO2.ClH
• Molecular Weight: 265.73534
• Hs Code.: 2922299090
• Mol file: 1159825-08-7.mol

Synonyms:4-Benzyloxy-3-Methoxy-phenylaMine HCl;4-(Benzyloxy)-3-Methoxyaniline hydrochloride;3-Methoxy-4-(phenylmethoxy)benzenamine hydrochloride (1:1)

Chemical Property of 4-Benzyloxy-3-Methoxy-phenylaMine HCl

Chemical Property:

• PSA: 44.48000
• LogP: 4.23960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(Benzyloxy)-3-methoxyanilinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxy-3-Methoxy-phenylaMine HCl

There total 2 articles about 4-Benzyloxy-3-Methoxy-phenylaMine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzyloxy)-2-methoxy-4-nitrobenzene (107922-43-0) → 4-benzyloxy-3-methoxy-phenylamine hydrochloride (1159825-08-7)

Guidance literature:

1-(benzyloxy)-2-methoxy-4-nitrobenzene; With tin(II) chloride dihdyrate; In tert-butyl alcohol; for 4h; Reflux;

With hydrogenchloride; In ethyl acetate;

Reference yield:

2-fluoro-5-nitrophenol (22510-08-3) → 4-benzyloxy-3-methoxy-phenylamine hydrochloride (1159825-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 1 h / 20 °C

3.1: tin(II) chloride dihdyrate / tert-butyl alcohol / 4 h / Reflux

With tin(II) chloride dihdyrate; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;

upstream raw materials:

2-fluoro-5-nitrophenol

1-(benzyloxy)-2-methoxy-4-nitrobenzene

Refernces