1-Octadecanol, 18-bromo-

Base Information

• Chemical Name: 1-Octadecanol, 18-bromo-
• CAS No.: 59101-17-6
• Molecular Formula: C18H37BrO
• Molecular Weight: 349.395
• Mol file: 59101-17-6.mol

Synonyms:

Chemical Property of 1-Octadecanol, 18-bromo-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Octadecanol, 18-bromo-

There total 8 articles about 1-Octadecanol, 18-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

octadecane-1,18-diol (3155-43-9) → 18-bromooctadecan-1-ol (59101-17-6)

Guidance literature:

octadecane-1,18-diol; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Inert atmosphere; Cooling with ice;

With lithium bromide; In tetrahydrofuran; Reflux;

Reference yield:

18-bromooctadecanoic acid (2536-38-1) → 18-bromooctadecan-1-ol (59101-17-6)

Guidance literature:

With diborane; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00229a018

Reference yield:

dimethyl 1,18-octadecanedioate (1472-93-1) → 18-bromooctadecan-1-ol (59101-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux; Inert atmosphere

2: hydrogen bromide / water; toluene / 48 h / 120 °C / Inert atmosphere

With lithium aluminium tetrahydride; hydrogen bromide; In tetrahydrofuran; water; toluene;

DOI:10.1021/acsmedchemlett.9b00477

upstream raw materials:

18-bromooctadecanoic acid

9-bromononan-1-ol

2-(9-bromononyloxy)tetrahydropyran

octadecane-1,18-diol

Downstream raw materials:

4-(18-Hydroxy-octadecyloxy)-benzoic acid methyl ester

4-(18-Mercapto-octadecyloxy)-benzoic acid

4-(18-Acetylsulfanyl-octadecyloxy)-benzoic acid methyl ester

4-(18-Methanesulfonyloxy-octadecyloxy)-benzoic acid methyl ester

Refernces

• 1、 -. "Compositions and methods for binding lysophosphatidic acid". . . Retrieved 2015/11/10.