(R)-1-(4-CHLOROPHENYL)ETHANOL

Base Information

• Chemical Name: (R)-1-(4-CHLOROPHENYL)ETHANOL
• CAS No.: 1517-70-0
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Hs Code.: 2909498090
• Mol file: 1517-70-0.mol

Synonyms:Benzenemethanol, 4-methoxy-α-methyl-, (R)-;(+)-(R)-1-(4-Methoxyphenyl)ethanol;(+)-1-(p-Methoxyphenyl)ethanol;(αR)-4-Methoxy-α-methylbenzenemethanol;

Chemical Property of (R)-1-(4-CHLOROPHENYL)ETHANOL

Chemical Property:

• Boiling Point: 254.344 °C at 760 mmHg
• PKA: 14.49±0.20(Predicted)
• Flash Point: 107.969 °C
• PSA: 29.46000
• Density: 1.053 g/cm³
• LogP: 1.74850
• Storage Temp.: 2-8°C

Purity/Quality:

99.5% ^*data from raw suppliers

(R)-1-(4-Methoxyphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(4-CHLOROPHENYL)ETHANOL

There total 219 articles about (R)-1-(4-CHLOROPHENYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

isopropyl butyrate (638-11-9) + rac-1-(4-methoxyphenyl)-ethanol (3319-15-1) → (S)-1-(4-Methoxyphenyl)ethanol (1517-70-0,1572-97-0,3319-15-1,43230-31-5) + (R)-1-(4-Methoxyphenyl)ethanol (1517-70-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) + (R)-α-methyl-4-methoxybenzyl butyrate

Guidance literature:

With [(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one; In toluene; at 70 ℃; for 40h; under 142.511 Torr;

DOI:10.1016/j.tetasy.2005.02.028

Reference yield: 80.0%

isopropyl butyrate (638-11-9) + rac-1-(4-methoxyphenyl)-ethanol (3319-15-1) → (S)-1-(4-Methoxyphenyl)ethanol (1517-70-0,1572-97-0,3319-15-1,43230-31-5) + (R)-1-(4-Methoxyphenyl)ethanol (1517-70-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) + (R)-α-methyl-4-methoxybenzyl butyrate

Guidance literature:

With [(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one; In toluene; at 70 ℃; for 40h; under 142.511 Torr;

DOI:10.1016/j.tetasy.2005.02.028

Reference yield: 80.0%

2-Bromo-4'-methoxyacetophenone (2632-13-5) → (R)-1-(4-Methoxyphenyl)ethanol (1517-70-0) + (S)-1-bromo-2-hydroxy-2-(p-methoxyphenyl)ethane (19922-83-9) + 1-(4-methoxyphenyl)ethanone (100-06-1)

Guidance literature:

With sodium formate; cetyltrimethylammonim bromide; sodium dodecyl-sulfate; (R,R)-TsDPEN; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In water; at 28 ℃; for 1h;

DOI:10.1021/jo0514826

upstream raw materials:

4-Methoxystyrene

Isopropenyl acetate

rac-1-(4-methoxyphenyl)-ethanol

(-)-(S)-N,N-dimethyl-1-phenylethylamine

Downstream raw materials:

(S)-1-(4-Methoxyphenyl)ethanol

1-(4-methoxyphenyl)-1-(allyloxy)ethane

(S)-1-(4-methoxyphenyl)ethyl acetate

(S)-N,N-diisopropyl O-[1-(4-methoxyphenyl)]ethyl carbamate

Refernces

• 1、 Debbeche, Hanane,Toffano, Martial,Fiaud, Jean-Claude,Aribi-Zouioueche, Louisa. "Multi-substrate screening for lipase-catalyzed resolution of arylalkylethanols with succinic anhydride as acylating agent". . p. 319 - 324. Retrieved 2010.
• 2、 He, Wei,Zhang, Bang-Le,Jiang, Ru,Liu, Peng,Sun, Xiao-Li,Zhang, Sheng-Yong. "Novel recoverable catalysts for asymmetric transfer hydrogenation". . p. 5367 - 5370. Retrieved 2006.
• 3、 Ghosh, Anirban,Kumar, Rajiv. "Efficient heterogeneous catalytic systems for enantioselective hydrogenation of prochiral carbonyl compounds". . p. 386 - 396. Retrieved 2004.
• 4、 Patti, Angela,Pedotti, Sonia. "Screening of chiral ferrocenyl amino alcohols as ligands for ruthenium-catalysed transfer hydrogenation of ketones". . p. 597 - 602. Retrieved 2003.
• 5、 Deng, Jia,Lu, Cuifen,Yang, Guichun,Chen, Zuxing. "Preparation of microgel-supported chiral catalysts and their application in the asymmetric hydrogenation of aromatic ketones". . p. 378 - 382. Retrieved 2012.
• 6、 Coverdale, James P. C.,Sanchez-Cano, Carlos,Clarkson, Guy J.,Soni, Rina,Wills, Martin,Sadler, Peter J.. "Easy to Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts". . p. 8043 - 8046. Retrieved 2015.
• 7、 Yang, Teng-Kuei,Lee, Dong-Sheng. "Application of MerCO as a chiral catalyst in asymmetric synthesis: Asymmetric borane reduction of ketones". . p. 405 - 409. Retrieved 1999.
• 8、 He, Bingbing,Tang, Fengci,Sun, Chenrui,Su, Jiahao,Wu, Bingcheng,Chen, Yan,Xiao, Yuquan,Zhang, Panliang,Tang, Kewen. "Resolution of (R,S)-1-(4-methoxyphenyl)ethanol by lipase-catalyzed stereoselective transesterification and the process optimization". . p. 438 - 445. Retrieved 2021/12/17.
• 9、 Kolcsár, Vanessza Judit,Sz?ll?si, Gy?rgy. "Chitosan as a chiral ligand and organocatalyst: Preparation conditions-property-catalytic performance relationships". . p. 7652 - 7666. Retrieved 2021/12/13.