Imidazo[1,2-a]pyridin-7-amine (9CI)

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-7-amine (9CI)
• CAS No.: 421595-81-5
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 421595-81-5.mol

Synonyms:Imidazo[1,2-a]pyridin-7-amine (9CI);Imidazo[1,2-a]pyridin-7-amine;H-imidazo[1,2-a]pyridin-7-amine;7-Aminoimidazo[1,2-a]pyridine

Chemical Property of Imidazo[1,2-a]pyridin-7-amine (9CI)

Chemical Property:

• PKA: 8.98±0.50(Predicted)
• PSA: 43.32000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 1.49770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridin-7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridin-7-amine (9CI)

There total 9 articles about Imidazo[1,2-a]pyridin-7-amine (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl N-(imidazo[1,2-a]pyridin-7-yl)carbamate (421596-48-7) → imidazo[1,2-a]pyridin-7-amine (421595-81-5)

Guidance literature:

With sodium hydroxide; for 7h; Heating;

DOI:10.1016/S0040-4020(01)01141-3

Reference yield: 82.0%

N-(diphenylmethylene)imidazo[1,2-a]pyridin-7-amine → imidazo[1,2-a]pyridin-7-amine (421595-81-5)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃;

Reference yield: 73.0%

7-chloroimidazo-[1,2-a]pyridine (4532-25-6) → imidazo[1,2-a]pyridin-7-amine (421595-81-5)

Guidance literature:

With ammonium hydroxide; potassium phosphate; copper(l) iodide; N¹,N²-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide; In water; dimethyl sulfoxide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03230

upstream raw materials:

ethyl N-(imidazo[1,2-a]pyridin-7-yl)carbamate

imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester

imidazo[1,2-a]pyridine-7-carbonyl azide

imidazo[1,2-a]pyridine-7-carbohydrazide

Downstream raw materials:

3-[3-(4-fluoro-phenoxy)-benzyl]-piperidine-1-carboxylic acid imidazo[1,2-a]pyridin-7-ylamide

C₂₂H₂₂ClN₅O₂

N-imidazo[1,2-a]pyridin-7-yl-3-oxo-3-phenylpropanamide

9-(3',4',5'-trimethoxyphenyl)imidazo[2,1-f][1,6]naphthyridin-10(7H)-one

Refernces

• 1、 -. "HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE". Paragraph 0266-0267. . Retrieved 2019/05/15.
• 2、 -. "Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)". . . Retrieved 2019/06/07.