Ethyl imidazo[1,2-a]pyridine-7-carboxylate

Base Information

• Chemical Name: Ethyl imidazo[1,2-a]pyridine-7-carboxylate
• CAS No.: 372147-49-4
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• European Community (EC) Number: 689-848-6
• DSSTox Substance ID: DTXSID70472811
• Nikkaji Number: J1.659.017G
• Wikidata: Q72475452
• Mol file: 372147-49-4.mol

Synonyms:Ethyl imidazo[1,2-a]pyridine-7-carboxylate;372147-49-4;Imidazo[1,2-a]pyridine-7-carboxylic acid, ethyl ester;MFCD08436046;Ethyl H-imidazo[1,2-a]pyridine-7-carboxylate;EthylImidazo[1,2-a]pyridine-7-carboxylate;SCHEMBL556235;DTXSID70472811;UWYWNAGXCZHLLM-UHFFFAOYSA-N;AMY20506;AKOS006346252;ME-0243;SY015645;Ethylh-imidazo[1,2-a]pyridine-2-carboxylate;FT-0682724;A874146;Ethyl Imidazo[1 pound not2-a]pyridine-7-carboxylate;J-521248

Chemical Property of Ethyl imidazo[1,2-a]pyridine-7-carboxylate

Chemical Property:

• Melting Point: 79-81 °C
• Refractive Index: 1.594
• PSA: 43.60000
• Density: 1.228 g/cm³
• LogP: 1.51100
• Storage Temp.: Keep Cold
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 190.074227566
• Heavy Atom Count: 14
• Complexity: 220

Purity/Quality:

99% ^*data from raw suppliers

Ethylimidazo[1,2-a]pyridine-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC2=NC=CN2C=C1

Technology Process of Ethyl imidazo[1,2-a]pyridine-7-carboxylate

There total 4 articles about Ethyl imidazo[1,2-a]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-bromocrotonic ethyl ester (6065-32-3) + 2-imidazolecarbaldehyde (10111-08-7) → imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester (372147-49-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.3987/COM-09-11856

Reference yield: 81.0%

2-chloroethanal (107-20-0) + 2-amino-4-ethoxycarbonyl-pyridine (13362-30-6) → imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester (372147-49-4)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; for 9h; Heating;

DOI:10.1021/jo015582x DOI:10.1016/S0040-4020(01)01141-3

Reference yield: 72.0%

ethanol (64-17-5) + imidazo[1,2-a]pyridine-7-carbonyl azide (421595-79-1) → imidazo[1,2-a]pyridine-7-carboxylic acid ethyl ester (372147-49-4) + ethyl N-(imidazo[1,2-a]pyridin-7-yl)carbamate (421596-48-7)

Guidance literature:

for 4.5h; Heating;

DOI:10.1016/S0040-4020(01)01141-3

upstream raw materials:

2-chloroethanal

2-amino-4-ethoxycarbonyl-pyridine

ethanol

imidazo[1,2-a]pyridine-7-carbonyl azide

Downstream raw materials:

N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide

N-(triphenyl-λ⁵-phosphanylidene)imidazo[1,2-a]pyridin-7-amine

imidazo[1,2-a]pyridin-7-amine

7-hydroxymethylimidazo[1,2-a]pyridine

Refernces

• 1、 Chezal, Jean M,Moreau, Emmanuel,Chavignon, Olivier,Gaumet, Vincent,Métin, Jacques,Blache, Yves,Diez, Anna,Fradera, Xavier,Luque, Javier,Teulade, Jean C. "Aminoimidazo[1,2-a]pyridines: Regioselective synthesis of substituted imidazonaphthyridines, azacarbolines and cyclazines". . p. 295 - 307. Retrieved 2007/10/03.