Linderaspirone A

Base Information

• Chemical Name: Linderaspirone A
• CAS No.: 1235126-46-1
• Molecular Formula: C34H32O10
• Molecular Weight: 600.61
• Mol file: 1235126-46-1.mol

Synonyms:Linderaspirone A

Chemical Property of Linderaspirone A

Chemical Property:

• Boiling Point: 826.5±65.0 °C(Predicted)
• PSA: 123.66000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 3.91340

Purity/Quality:

98%min ^*data from raw suppliers

LinderaspironeA 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Linderaspirone A

There total 23 articles about Linderaspirone A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Methyllinderone (3984-73-4) → linderaspirone A (1235126-53-0,1235126-46-1) + C34H32O10 + bilinderone (1227375-09-8) + epi-bi-linderone (1227375-09-8)

Guidance literature:

In hexane; acetone; at 20 ℃; for 8h; Inert atmosphere; Irradiation;

DOI:10.1021/ol200418e

Reference yield: 54.0%

Methyllinderone (3984-73-4) → (+/-)-bi-linderone (1227375-09-8) + (+/-)-linderaspirone A (1235126-46-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In toluene; at 80 ℃; for 20h;

DOI:10.1016/j.tetlet.2011.03.081

Reference yield:

3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) → linderaspirone A (1235126-53-0,1235126-46-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.1: lead(IV) tetraacetate / toluene / 1 h / 20 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / Inert atmosphere; Reflux

3.2: 0.25 h / -78 °C

4.1: potassium hydroxide / tetrahydrofuran; diethyl ether; water / 1 h / 70 °C

5.1: 24 h / 20 °C / Inert atmosphere; Irradiation; Neat (no solvent)

With sodium methylate; lead(IV) tetraacetate; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; toluene;

DOI:10.1021/ol200418e

upstream raw materials:

Methyllinderone

(E)-3,4-dimethoxy-5-((E)-2-oxo-4-phenylbut-3-en-1-ylidene)furan-2(5H)-one

(E)-4-hydroxy-2,3-dimethoxy-4-(2-oxo-4-phenylbut-3-en-1-yl)cyclobut-2-enone

Linderone

Refernces

• 1、 Wang, Gang-Qiang,Wei, Kun,Zhang, Lin,Feng, Tao,Wang, Fei,Wang, Qiu-An,Liu, Ji-Kai. "One-step biomimetic synthesis of (±)-linderaspirone A and (±)-bi-linderone". body text. p. 2719 - 2721. Retrieved 2011/06/19.