2-(4-Methoxyphenyl)ethylazanium;chloride

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)ethylazanium;chloride
• CAS No.: 645-58-9
• Molecular Formula: C9H14ClNO
• Molecular Weight: 187.669
• Hs Code.: 2922299090
• Mol file: 645-58-9.mol

Synonyms:

Chemical Property of 2-(4-Methoxyphenyl)ethylazanium;chloride

Chemical Property:

• Melting Point: 210 °C
• Boiling Point: 255.2 °C at 760 mmHg
• Flash Point: 105.3 °C
• PSA: 35.25000
• Density: 1.008g/cm³
• LogP: 2.69870
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 187.0763918
• Heavy Atom Count: 12
• Complexity: 97.7

Purity/Quality:

98.5% ^*data from raw suppliers

2-(4-Methoxyphenyl)ethylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC[NH3+].[Cl-]
• Uses: 2-(4-Methoxyphenyl)ethylamine is used in the synthesis of 1,3-disubstituted β-carboline alkaloids. It is also used in the preparation of antibacterial lysine-peptoid hybrids.

Technology Process of 2-(4-Methoxyphenyl)ethylazanium;chloride

There total 8 articles about 2-(4-Methoxyphenyl)ethylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-methoxybenzylnitrile (104-47-2) → 4-methoxyphenethylamine hydrochloride (645-58-9)

Guidance literature:

With hydrogenchloride; hydrogen; In propan-1-ol; water; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 88.0%

4-Methoxyphenethylamine (55-81-2) → 4-methoxyphenethylamine hydrochloride (645-58-9)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7cy01577a

Reference yield: 67.0%

2-(4-methoxyphenyl)acetamide (6343-93-7) → 4-methoxyphenethylamine hydrochloride (645-58-9)

Guidance literature:

2-(4-methoxyphenyl)acetamide; With dodecacarbonyl-triangulo-triruthenium; 1,1,3,3-tetramethyldisilazane; In toluene; at 20 - 70 ℃; for 24.17h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; toluene; at 20 ℃; for 0.5h;

DOI:10.1002/adsc.201200835

upstream raw materials:

3-<(E)-<2-(4-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone

1-(2-Chloroethyl)-4-methoxybenzene

2-(4-methoxyphenyl)acetamide

p-methoxybenzylnitrile

Downstream raw materials:

2-{[2-(4-Methoxy-phenyl)-ethylamino]-methyl}-3,4-dihydro-2H-naphthalen-1-one

2-(1H-Indol-3-yl)-N-[2-(4-methoxy-phenyl)-ethyl]-2-oxo-acetamide

N-[2-(4-methoxyphenyl)ethyl]benzamide

N-1-(4-methoxy)phenethylbiguanide hydrochloride

Refernces

• 1、 Ferraccioli, Raffaella,Borovika, Diana,Surkus, Annette-Enrica,Kreyenschulte, Carsten,Topf, Christoph,Beller, Matthias. "Synthesis of cobalt nanoparticles by pyrolysis of Vitamin B12: A non-noble-metal catalyst for efficient hydrogenation of nitriles". . p. 499 - 507. Retrieved 2018/02/07.
• 2、 Saito, Yuki,Ishitani, Haruro,Ueno, Masaharu,Kobayashi, Shū. "Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions". . p. 211 - 215. Retrieved 2017/04/21.