3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid

Base Information

• Chemical Name: 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid
• CAS No.: 886588-62-1
• Molecular Formula: C13H14N2O2.C4H6O6
• Molecular Weight: 380.3493
• Mol file: 886588-62-1.mol

Synonyms:2-(3R)-3-Piperidinyl-1H-Isoindole-1,3(2H)-Dione D-(-)-Tartarate

Chemical Property of 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid

Chemical Property:

• PSA: 164.47000
• LogP: -0.82130
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

(R)-2-(Piperidin-3-yl)isoindoline-1,3-dione(2S,3S)-2,3-dihydroxysuccinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid

There total 1 articles about 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(phthalimido)piperidine (62813-09-6,886588-71-2) + D-tartaric acid (147-71-7,138508-61-9) → (R)-2-(piperidin-3-yl)isoindoline-1,3-dione D-(-)-tartaric acid salt (886588-62-1)

Guidance literature:

In ethanol; at 90 ℃; for 0.5h;

Reference yield: 94.0%

2-bromo-1-(but-2-ynyl)-4-methyl-6-((4-methylquinazolin-2-yl)methyl)-1H-imidazo[4,5-b]pyridine-5,7-(4H,6H)-dione (853029-57-9) + (R)-2-(piperidin-3-yl)isoindoline-1,3-dione D-(-)-tartaric acid salt (886588-62-1) → (R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine2,6-dione (886588-63-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 2h;

DOI:10.3390/molecules21081041

upstream raw materials:

3-(phthalimido)piperidine

D-tartaric acid

Downstream raw materials:

(R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine2,6-dione

Refernces

• 1、 -. "METHOD FOR PRODUCING CHIRAL 8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES". Page/Page column 6; 8. . Retrieved 2008/06/13.