N-(2-cyanophenyl)-N-methylmethanesulfonamide

Base Information

• Chemical Name: N-(2-cyanophenyl)-N-methylmethanesulfonamide
• CAS No.: 1073159-70-2
• Molecular Formula: C9H10N2O2S
• Molecular Weight: 210.257
• Hs Code.: 2935009090
• Mol file: 1073159-70-2.mol

Synonyms:N-(2-cyanophenyl)-N-methylmethanesulfonamide;Methanesulfonamide, N-(2-cyanophenyl)-N-methyl-

Chemical Property of N-(2-cyanophenyl)-N-methylmethanesulfonamide

Chemical Property:

• Boiling Point: 365.6±44.0 °C(Predicted)
• PKA: -4.38±0.50(Predicted)
• PSA: 69.55000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 2.03488
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Cyanophenyl)-N-methylmethanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-cyanophenyl)-N-methylmethanesulfonamide

There total 2 articles about N-(2-cyanophenyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-benzonitrile (235100-91-1) + methyl iodide (74-88-4) → N-(2-cyanophenyl)-N-methylmethanesulfonamide (1073159-70-2)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

Reference yield: 88.9%

N-methylmethane sulphonamide (1184-85-6) + 2-fluorobenzonitrile (394-47-8) → N-(2-cyanophenyl)-N-methylmethanesulfonamide (1073159-70-2)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃;

Reference yield: 100.0%

N-(2-cyanophenyl)-N-methylmethanesulfonamide (1073159-70-2) → N-[2-(aminomethyl)phenyl]-N-methylmethanesulfonamide (869371-40-4)

Guidance literature:

With ammonia; hydrogen; palladium 10% on activated carbon; In methanol; water; under 2585.81 Torr;

upstream raw materials:

2-benzonitrile

methyl iodide

N-methylmethane sulphonamide

2-fluorobenzonitrile

Downstream raw materials:

N-(2-aminomethyl-phenyl)-N-methyl-methanesulfonamide acetate

N-[2-(aminomethyl)phenyl]-N-methylmethanesulfonamide

N-(2-((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)methyl)phenyl)-N-methylmethanesulfonamide

N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

Refernces

• 1、 Wang, Ruifeng,Chen, Yixuan,Zhao, Xiangxin,Yu, Sijia,Yang, Bowen,Wu, Tianxiao,Guo, Jing,Hao, Chenzhou,Zhao, Dongmei,Cheng, Maosheng. "Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents". . . Retrieved 2019/09/30.
• 2、 -. "2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS". Page/Page column 68. . Retrieved 2012/07/27.