2-Fluoro-4,6-dichlorobenzoic acid

Base Information

• Chemical Name: 2-Fluoro-4,6-dichlorobenzoic acid
• CAS No.: 904285-09-2
• Molecular Formula: C7H3Cl2FO2
• Molecular Weight: 209.004
• Hs Code.: 2916399090
• Mol file: 904285-09-2.mol

Synonyms:2,4-Dichloro-6-fluorobenzoic acid; Benzoic acid, 2,4-dichloro-6-fluoro-; 2-Fluoro-4,6-dichlorobenzoicacid; 2-Fluoro-4,6-dichlorobenzoic acid

Chemical Property of 2-Fluoro-4,6-dichlorobenzoic acid

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 291 oC
• Flash Point: 130 oC
• PSA: 37.30000
• Density: 1.606
• LogP: 2.83070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-6-fluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-4,6-dichlorobenzoic acid

There total 2 articles about 2-Fluoro-4,6-dichlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,4-dichloro-6-fluorobenzaldehyde (681435-09-6) → 2,4-dichloro-6-fluorobenzoic acid (904285-09-2)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In acetonitrile; tert-butyl alcohol; at 0 - 20 ℃; for 1h; Temperature;

Reference yield: 35.0%

carbon dioxide (124-38-9,18923-20-1) → 2,4-dichloro-6-fluorobenzoic acid (904285-09-2)

Guidance literature:

1-fluoro-3,5-dichlorobenzene; With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; at -78 ℃; for 1.33333h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.166667h;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield: 60.0%

2,4-dichloro-6-fluorobenzoic acid (904285-09-2) + m-aminobenzenesulfonamide (98-18-0) → 2,4-dichloro-6-fluoro-N-(3-sulfamoylphenyl)benzamide

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

carbon dioxide

2,4-dichloro-6-fluorobenzaldehyde

Downstream raw materials:

2,4-dichloro-6-fluorophenylacetic acid methyl ester

2,4-dichloro-6-fluorophenylacetic acid

Refernces

• 1、 -. "Dihydroquinazolinones as 5HT modulators". Page/Page column 17. . Retrieved 2008/06/13.