2,4-dichloro-6-fluorophenylacetic acid methyl ester

Base Information

• Chemical Name: 2,4-dichloro-6-fluorophenylacetic acid methyl ester
• CAS No.: 1421620-41-8
• Molecular Formula: C₉H₇Cl₂FO₂
• Molecular Weight: 237.058
• Mol file: 1421620-41-8.mol

Synonyms:2,4-dichloro-6-fluorophenylacetic acid methyl ester

Chemical Property of 2,4-dichloro-6-fluorophenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-6-fluorophenylacetic acid methyl ester

There total 3 articles about 2,4-dichloro-6-fluorophenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + dichloro-6-fluorobenzoic acid → 2,4-dichloro-6-fluorophenylacetic acid methyl ester (1421620-41-8)

Guidance literature:

With silver benzoate; triethylamine; at 20 ℃; Cooling with ice;

Reference yield:

2,4-dichloro-6-fluorobenzoic acid (904285-09-2) → 2,4-dichloro-6-fluorophenylacetic acid methyl ester (1421620-41-8)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / -5 - 20 °C

2: hexane; tetrahydrofuran / 2 h / -5 - 20 °C

3: triethylamine; silver benzoate / 20 °C / Cooling with ice

With oxalyl dichloride; silver benzoate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

2,4-dichloro-6-fluorobenzoyl chloride → 2,4-dichloro-6-fluorophenylacetic acid methyl ester (1421620-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hexane; tetrahydrofuran / 2 h / -5 - 20 °C

2: triethylamine; silver benzoate / 20 °C / Cooling with ice

With silver benzoate; triethylamine; In tetrahydrofuran; hexane;

upstream raw materials:

2,4-dichloro-6-fluorobenzoic acid

methanol

Downstream raw materials:

2,4-dichloro-6-fluorophenylacetic acid

Refernces

• 1、 -. "HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS". . . Retrieved 2013/03/26.