(R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride

Base Information

• Chemical Name: (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride
• CAS No.: 521284-21-9
• Molecular Formula: C16H18N2O3.ClH
• Molecular Weight: 322.791
• Hs Code.: 2922199090
• Mol file: 521284-21-9.mol

Synonyms:Benzenemethanol, a-[[[2-(4-nitrophenyl)ethyl]amino]methyl]-, monohydrochloride, (aR)-; Mirabegron Intermediate 3; (R)-2-(4-nitrophenethylamino)-1-phenylethanol monohydrochloride; R-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol hydrochloride; (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol HCL

Chemical Property of (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride

Chemical Property:

• PSA: 78.08000
• LogP: 4.17660
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-((4-nitrophenethyl)amino)-1-phenylethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-2-((4-nitrophenethyl)amino)-1-phenylethanol is an intermediate used to prepare (aminothiazolyl)acetanilide derivatives via coupling reactions for treatment of diabetes.

Technology Process of (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride

There total 9 articles about (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

2-(p-nitrophenyl)ethylamine (24954-67-4) + 2-chloro-1-phenylethanol (56751-12-3) → (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydrochloride (521284-21-9)

Guidance literature:

In methanol; at 60 - 65 ℃; for 48h; Temperature;

Reference yield: 90.5%

(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide (521284-19-5) → (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydrochloride (521284-21-9)

Guidance literature:

(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 2 ℃; for 10h; Reflux;

With methanol; In tetrahydrofuran; at 5 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 10 ℃; for 0.5h; Solvent; Reagent/catalyst; Temperature;

Reference yield: 85.0%

(R)-2-(4-nitrophenylethylamino)-1-phenylethan-1-ol hydrochloride (223673-34-5) → (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydrochloride (521284-21-9)

Guidance literature:

With hydrogenchloride; In water; tert-butyl alcohol; at 20 ℃; for 12h; Solvent;

upstream raw materials:

(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide

(R)-Styrene oxide

2-(4-nitrophenyl)ethylamine monohydrochloride

2-(p-nitrophenyl)ethylamine

Downstream raw materials:

(R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride

YM-208876

((2R)-2-hydroxy-2-phenylethyl)-[2-(4-nitrophenyl)ethyl]carbamic acid tert-butyl ester

(R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester

Refernces

• 1、 -. "Synthetic method (1R)-2-[[[2-(4-nitrophenyl) ethyl] amino] methyl] phenylmethylamine hydrochloride". Paragraph 0017-0019. . Retrieved 2020/03/17.
• 2、 -. "Synthetic method of mirabegron intermediate". Paragraph 0016; 0019-0020. . Retrieved 2017/04/03.