5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER
• CAS No.: 886365-25-9
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• Hs Code.: 2933399990
• Mol file: 886365-25-9.mol

Synonyms:4-Pyridinecarboxylic acid, 5-bromo-2-methoxy-, methyl ester;

Chemical Property of 5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER

Chemical Property:

• PSA: 48.42000
• LogP: 1.63930
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl 5-bromo-2-methoxyisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER

There total 5 articles about 5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 5-bromo-2-methoxypyridine-4-carboxylic acid (886365-22-6) → methyl 5-bromo-2-methoxy-pyridine-4-carboxylate (886365-25-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 77.0%

methyl 5-bromo-2-hydroxypyridine-4-carboxylate + methyl iodide (74-88-4) → methyl 5-bromo-2-methoxy-pyridine-4-carboxylate (886365-25-9)

Guidance literature:

With silver (II) carbonate; In toluene; at 50 ℃; for 15h;

Reference yield:

methanol (67-56-1) + 5-bromo-2-methoxy-pyridine-4-carbaldehyde (936011-17-5) → methyl 5-bromo-2-methoxy-pyridine-4-carboxylate (886365-25-9)

Guidance literature:

With iodine; potassium hydroxide; at 0 ℃; for 1h;

upstream raw materials:

methanol

5-bromo-2-methoxypyridine-4-carboxylic acid

5-bromo-2-methoxy-pyridine-4-carbaldehyde

2-methoxy-5-bromopyridine

Downstream raw materials:

C₆H₄BrNO₃

methyl 5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate

7-methoxy-1,2,3,4-tetrahydro-2,6-naphthyridine

5-bromo-2-methoxypyridine-4-carboxylic acid

Refernces

• 1、 -. "THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS". Paragraph 0536. . Retrieved 2020/12/11.
• 2、 -. "BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF". Page/Page column 74. . Retrieved 2018/05/15.