3-Ethynylimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 3-Ethynylimidazo[1,2-b]pyridazine
• CAS No.: 943320-61-4
• Molecular Formula: C₈H₅N₃
• Molecular Weight: 143.148
• Hs Code.: 2933998090
• Mol file: 943320-61-4.mol

Synonyms:Imidazo[1,2-b]pyridazine,3-ethynyl;3-ETHYNYLIMIDAZOLO[1,2-B]PYRIDAZINE;

Chemical Property of 3-Ethynylimidazo[1,2-b]pyridazine

Chemical Property:

• PKA: 3.71±0.30(Predicted)
• PSA: 30.19000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 0.71060
• Storage Temp.: 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

3-Ethynylimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethynylimidazo[1,2-b]pyridazine

There total 6 articles about 3-Ethynylimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

2-imidazo[1,2-b]pyridazin-3-ylethynyl(trimethyl)silane (943320-60-3) → 3-ethynyl-imidazo[1,2-b]pyridazine (943320-61-4)

Guidance literature:

With potassium fluoride; In methanol; at 20 ℃; for 0.333333h;

Reference yield: 82.0%

C13H11N3O3S + acetylene (74-86-2,25067-58-7) → 3-ethynyl-imidazo[1,2-b]pyridazine (943320-61-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 3h; under 3000.3 Torr; Pressure; Temperature; Autoclave; Inert atmosphere;

Reference yield: 74.0%

3-bromo-imidazo[1,2-b]pyridazine (18087-73-5) + trimethylsilylacetylene (1066-54-2) → 3-ethynyl-imidazo[1,2-b]pyridazine (943320-61-4)

Guidance literature:

3-bromo-imidazo[1,2-b]pyridazine; With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; triethylamine; triphenylphosphine; In acetonitrile; for 0.5h; Sealed tube; Inert atmosphere; Microwave irradiation;

trimethylsilylacetylene; In acetonitrile; at 80 ℃; Inert atmosphere; Microwave irradiation;

With methanol; potassium carbonate; for 1h;

upstream raw materials:

2-imidazo[1,2-b]pyridazin-3-ylethynyl(trimethyl)silane

3-bromo-imidazo[1,2-b]pyridazine

trimethylsilylacetylene

imidazo[1.2-b]pyridazine

Refernces

• 1、 -. "COMPOUNDS USEFUL FOR INHIBITING RAF DIMERS". Paragraph 0151; 0154. . Retrieved 2020/09/12.
• 2、 -. "BTK Inhibitors and uses thereof". Paragraph 1587; 1593-1595. . Retrieved 2020/05/02.