Methyl

Base Information

• Chemical Name: Methyl
• CAS No.: 57943-82-5
• Molecular Formula: C25H26Cl2N2O4
• Molecular Weight: 213.19
• Hs Code.: 9999999999
• Mol file: 57943-82-5.mol

Synonyms:3,4-Methylenedioxy AMphetaMine-d6 Hydrochloride

Chemical Property of Methyl

Chemical Property:

• Boiling Point: 425.6±45.0 °C(Predicted)
• PKA: 13.43±0.10(Predicted)
• PSA: 76.07000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: -1.06930
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Clavulanic Acid Methyl Ester is a substituted Clavulanic acid (C563750) as β-lactamase inhibitor. A labelled metabolite of MDMA. Entactogen; synthetic amphetamine derivative with stimulant and hallucinogenic properties. Controlled substance (hallucinogen).

Technology Process of Methyl

There total 15 articles about Methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + clavulanic acid (58001-44-8) → methyl clavulanate (57943-82-5)

Guidance literature:

In ethanol; Ambient temperature;

Reference yield: 48.0%

potassium clavulanate (57943-81-4) + methyl iodide (74-88-4) → methyl clavulanate (57943-82-5)

Guidance literature:

In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

Reference yield:

potassium clavulanate (57943-81-4) → methyl clavulanate (57943-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / dimethylformamide / 1.5 h / Ambient temperature

2: 1.) sodium hydrogen carbonate, H₂, 2.) potassium carbonate / 1.) palladium on carbon / 1.) aq. ethanol, 1 atm, ambient temperature, 3 days, 2.) N,N-dimethylformamide, overnight

With hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide;

upstream raw materials:

diazomethane

clavulanic acid

methanol

Benzyl Clavulanate

Downstream raw materials:

Benzyl Clavulanate

clavulanic acid

benzyl (5R)-7-oxo-3-vinyl-4-oxa-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

Refernces

• 1、 Brown, Allan G.,Corbett, David F.,Goodacre, Jennifer,Harbridge, John B.,Howarth, T. Trefor,et al.. "Clavulanic Acid and its Derivatives. Structure Elucidation of Clavulanic Acid and the Preparation of Dihydroclavulanic Acid, Isoclavulanic acid, Esters and Related Oxidation Products". . p. 635 - 650. Retrieved 2007/10/02.
• 2、 Bentley, Peter H.,Brooks, Gerald,Gilpin, Martin L.,Hunt, Eric. "A new total synthesis of (±)-clavulanic acid". . p. 1889 - 1890. Retrieved 2007/10/10.